ABSTRACT
Neonatal septicaemia is an important cause of neonatal morbidity and mortality. Blood culture is the gold standard for diagnosis of neonatal septicaemia. Several laboratory investigations are available to detect neonatal sepsis, one important is 'sepsis screen' which includes C-reactive protein (CRP), micro -ESR, total WBC count including immature to mature (VT) ratio and absolute neutrophil count. Blood culture was done among 210 samples from neonatal intensive care unit (NICU), RG Kar Medical College with suspected septicaemia along with CRP estimation. Among all the parameters, clinical correlation of CRP is significant; 65.2% of patients has blood culture positive. CRP positivity varied in different organisms. CRP is a non-specific acute phase reactant and rises significantly after 12 hours onwards. It can be used as an important parameter in infant at risk of septicaemia (significant > 6 mg/dl) and early institution of antimicrobials therapy. It has got prognostic value.
Subject(s)
C-Reactive Protein/metabolism , Sepsis/blood , Sepsis/microbiology , Anti-Bacterial Agents/therapeutic use , Blood/microbiology , Humans , Infant, Newborn , Intensive Care, Neonatal , Klebsiella/isolation & purification , Microbial Sensitivity Tests , Sepsis/diagnosis , Staphylococcus aureus/isolation & purification , Tertiary Care CentersABSTRACT
We describe two cases of Rosai-Dorfman disease. One of them had commonly described cervical adenopathy and the second with the very rare bilateral orbital involvement. Both our cases required treatment with steroids because of the danger of pressure symptoms and disfigurement and multiple episodes of high fever in one of them.
