ABSTRACT
The study was conducted as a part of research work "Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors". The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings. The object of the study were the white rats of WAG population. The effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols of such brands as AFS 9-4 ÐÐ, AFS 9-6 ÐÐ, AFS 9-10 ÐÐ on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment were studied. It was set that studied compounds during their subacute influence in a toxicological experiment stimulated the hydroxyling microsomal monooxygenase system of hepatocytes and inhibited reactions of the formation of glucuronid and glutathione conjugations against a background of more active processes of the formation of acetyl conjugation, higher levels in the content of CoA-SH, acetyl-CoA and ketone bodies.
Subject(s)
Liver/drug effects , Liver/metabolism , Phenols/toxicity , Surface-Active Agents/toxicity , Administration, Oral , Animals , Hepatocytes/drug effects , Hepatocytes/metabolism , Inactivation, Metabolic , Lethal Dose 50 , Microsomes, Liver/drug effects , Microsomes, Liver/metabolism , Phenols/chemistry , Rats , Solubility , Surface-Active Agents/chemistry , Toxicity Tests, SubacuteABSTRACT
The study was conducted as part of research work «Features of integrative and autonomic functions in the process of adaptation to the intellectual, emotional and physical stress" of the Department of Physiology of KhNMU. The aim of this work was to study the intersystem relationships that are the basis for the development of the body's resistance to the effects of stress factors, i.e., the development of adaptation syndrome in medical students. The object of the study were 217 students of 1-3 courses, which were examined in terms of the educational process. The features of intersystem integration the cardiorespiratory system on the basis of conjugation and integration of brain activity indeces based on intellectual efficiency in terms of a correction test. The study of the psychophysiological indicators complex in dynamics (3 years) revealed the formation of chronic emotional stress in medical students, the severity of which depends on the individual psychophysiological status of students. It was set that the formation of the adaptive optimum with psychoemotional stress occurs in only in 40% of students. Most of the students (60 %) indicate or initially insufficient adaptive capabilities, or an excessive rate, which naturally lead to psychological and autonomic disturbances in the organism.
