[Malignant lymphoma with "hairy" lymphocytes in the blood and splenomegaly--a new variant of lymphoproliferative diseases]. / Zlokachestvennaia limfoma s "volosatymi" limfotsitami v krovi i splenomegaliei--novyi variant limfoproliferativnogo zabolevaniia..

A total of 5 patients with a clinicohematological picture resembling hairy-cell leukemia (HCL) have been described. However, the morphological features of leukemic lymphocytes, the absence of acid phosphatase in them, the nodular character of the bone marrow lesion combined with an unusual phenotype have permitted the authors to distinguish these cases as a separate variant of B-cell malignant lymphoma. Paraprotein (M-class) was detected in the blood of two of the patients. A conclusion has been made that the combination of splenomegaly with hairy lymphocytes in the blood is characteristic of not only HCL, but it can be also observed in different variants of malignant lymphoma.

["Centrocytic leukemia"--a new variant of chronic lymphocytic leukemia?]. / "Tsentrotsitarnyi leikoz"--novyi variant khronicheskogo limfoleikoza?

A patient has been described with an unusual variant of B-cell lymphoid leukemia. Specific morphology of leukemic cells (the presence of nuclear cleavage), initial and principal localization of the process in the bone marrow, as well as an original phenotype of malignant cells (CD5+, CD35+, CD37+ and CD38+) have given the grounds for the designation of this rare variant of leukemia as centrocytic.

[2 phenotypic variants of B-cell lymphocytic leukemia]. / Dva fenotipicheskikh varianta B-kletochnogo khronicheskogo limfoleikoza.

A phenotype of lymphoid cells of peripheral blood in 38 patients with B-cel chronic lymphocytic leukaemia (B-CLL) was determined by means of a set of monoclonal antibodies. In the majority of the cases (32 persons--group I) the cells had an incomplete phenotype (CD 20+, CD 21-, CD 22-, CD 24+, CD 37+). In 6 patients (group II) cells had all the surface markers peculiar to B-CLL cells (phenotype--CD 20+, CD 21+, CD 22+, CD 24+, CD 37+). In 2 out of 6 cases lymphoid cells contained E-receptor (CD 2+). Cells of the patients from group I and II differed also in the level of TUI-receptor. An assumption is advanced about the existence of two phenotypic variants of B-CLL and about a possible association of CD 21 and CD 22 receptors.

[T-lymphocyte subpopulations in the blood of patients with chronic B-cell lympholeukemia studied using monoclonal antibodies]. / Issledovanie subpopuliatsii T-limfotsitov v krovi bol'nykh B-kletochnym khronicheskim limfoleikozom s pomoshch'iu monoklonal'nykh antitel.

The contents of T-lymphocytes and their basic subpopulations (T-helpers and T-suppressors) in peripheral blood of 40 patients with B-cellular chronic lymphatic leukemia was studied (CLL) using monoclonal antibodies. It is shown that an imbalance of T-helpers and T-suppressors is observed in many patients (a ratio of helpers/suppressors less than 1.29 in 24 patients) at the expense of a decrease in the relative content of T-helpers in patients at stage I-III of CLL and an increase in the contents of T-suppressors in patients at stage IV. A correlation is revealed between the ratio of T-helpers and T-suppressors, on the one hand, and the stage of the disease, on the other hand.