ABSTRACT
BACKGROUND: Cardiopulmonary involvement in systemic sclerosis (SSc) is a poor prognostic factor, due to pulmonary hypertension and right ventricular dysfunction. We assessed the echocardiographic parameters of right ventricular (RV) function in SSc and correlated echocardiographic findings to clinical features of the disease. METHODS: Thirty patients with SSc (cases) and 30 healthy, age-matched subjects (controls) were studied. Echocardiography, including tissue Doppler imaging, was used to evaluate cardiac function. RESULTS: Pulmonary hypertension could be documented in only 5 cases by Doppler echo, using Bernoulli principle. RV diastolic function was significantly deranged in cases. RV systolic function and left ventricle (LV) diastolic function were also significantly deranged in the cases. RV thickness was increased in patients with SSc. There were no significant differences in the echocardiographic variables between diffuse and limited subtypes of SSc. Myocardial performance index (MPI) of both ventricles were increased in cases. We could demonstrate RV thickness as the single most important predictor of MPI of both ventricles with sensitivity of 82% and specificity of 72% for RV-MPI and 63% for LV-MPI. Diastolic function was not found to be affected by disease duration or Rodnan skin score. CONCLUSION: Patients with SSc exhibit abnormal RV and LV diastolic functions as well as abnormal RV systolic function. RV wall thickness was found to be simple and the single best predictor of global myocardial performance. RV dysfunction may be a response to intermittent pulmonary arterial hypertension, lung parenchymal involvement, or secondary to LV diastolic dysfunction in SSc.
Subject(s)
Echocardiography, Doppler/methods , Heart Ventricles/diagnostic imaging , Hypertension, Pulmonary/complications , Scleroderma, Systemic/complications , Ventricular Dysfunction, Right/diagnosis , Ventricular Function, Right/physiology , Adult , Female , Heart Ventricles/physiopathology , Humans , Hypertension, Pulmonary/diagnosis , Hypertension, Pulmonary/physiopathology , Male , Reproducibility of Results , Ventricular Dysfunction, Right/etiology , Ventricular Dysfunction, Right/physiopathologyABSTRACT
Alloyed spherical FeNi-polymer nanocomposites were prepared via wet chemical method using hydrazine as a reducing agent and polymers (PVP and PEG) as reducing and stabilizing agent. Structural studies performed using XRD and TEM shows uniform dispersion of fine FeNi nanocrystallites in nanocomposite particles. The size and thermal stability of FeNi-polymer nanocomposite particles prepared under same reaction condition was found to be dependent on the type and the molecular weight of the polymer used. However, the magnetic properties of nanocomposite particles were not influenced by the polymers. The study highlights subtle differences in using polymers during the synthesis of alloyed nanocomposite particles.
