1.
Bioorg Med Chem Lett
; 19(16): 4622-5, 2009 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-19616430
ABSTRACT
A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.
Subject(s)
Cathepsins/antagonists & inhibitors , Protease Inhibitors/chemistry , Cathepsins/metabolism , Computer Simulation , Crystallography, X-Ray , Drug Design , Protease Inhibitors/chemical synthesis , Protease Inhibitors/pharmacology , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 19(15): 4280-3, 2009 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-19515558
ABSTRACT
A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.