[Compliance and insight as factors of recovery in patients with schizophrenia spectrum disorders]. / Komplaens i kritika k sostoyaniyu kak faktory vosstanovleniya patsientov s rasstroistvami shizofrenicheskogo spektra.

The goal of the up-to-date treatment of patients with schizophrenia spectrum disorders is recovery, including personal recovery. This goal is a part of the patient-centered approach. This review examines factors that may influence recovery achievement. Compliance plays a key role in relapse prevention. Its formation, in turn, depends on patients' participation in the treatment process, level of insight and patients' ability and willingness to play an active role in the treatment and apply self-management. All of the mentioned above should be taken into account while implementing patient-centered approach. This dictates the need to develop clear evaluation criteria of recovery factors in medical care of patients with schizophrenia spectrum disorders.

[Effects of diet on the gut microbiome in patients with depression]. / Vliyanie diety na mikrobiom kishechnika u patsientov s depressiei.

OBJECTIVE: To investigate the effects of diet on the gut microbiota and to assess the relationship of these factors with depression. MATERIAL AND METHODS: Microorganisms that predominate in depressed patients were identified and associations of the identified organisms with the patients' diet were performed. Fourteen depressed patients and 14 healthy volunteers with the same socio-demographic parameters were included in the study. The Hamilton Depression Scale, Generalized Anxiety Disorder Questionnaire, and the Center for Epidemiologic Studies Questionnaire were used. RESULTS: Erysipelatoclostridium and Clostridium innocuum species were 11.3 and 14.4 times higher in depressed patients compared with healthy controls. Fusicatenibacter saccharivorans, Faecalibacterium prausnitzii and Roseburia faecis species, as well as members of the genus Roseburia were statistically significantly more abundant in the healthy volunteers group (6.5, 2.14, 8.75 and 5.2 times more frequently compared to patients). The presence of these microorganisms was correlated with dietary components. CONCLUSION: Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet¼ on the development of depressive disorders.

[Metacognition as a pathway to the study and treatment of fragmentation in schizophrenia]. / Izuchenie i lechenie fragmentatsii pri shizofrenii s primeneniem kontseptsii metapoznaniya.

This paper explores the potential of recent research on metacognition to offer new avenues to assess and address the phenomenon of fragmentation in schizophrenia, which was described by E.Bleuler as «splitting¼. The concepts of metacognition characterize and quantify alterations or decrements in the processes by which fragments or pieces of information are integrated into a coherent sense of self and others. A method for assessing metacognition is presented along with research examining the presence and importance of metacognitive deficits in schizophrenia. Greater levels of metacognitive deficits have been detected in different phases of schizophrenia and linked to poorer psychosocial outcomes. These data were obtained both in foreign and preliminary Russian studies. The authors suggest that treatments, which successfully target metacognitive capacity, may uniquely promote wellness and recovery in schizophrenia.

[Impact of psychoeducation on compliance of inpatients with first episode psychosis]. / Vliyanie psikhoobrazovaniya na komplaentnost' patsientov s pervym psikhoticheskim epizodom v usloviyakh statsionara.

OBJECTIVE: To assess the impact of brief group inpatient psychoeducation interventions on compliance of patients with first episode psychosis (FEP) and emergency hospitalization. MATERIAL AND METHODS: One hundred and fifty-eight patients of treatment group and 79 patients of the control group were enrolled into the study. All patients were hospitalized emergently due to psychotic condition. Patients in treatment group had group psychoeducation sessions (5 sessions), patients in the control group received basic treatment only. Before discharge from the hospital, patients were accessed with PANSS, CGI-S, CGI-I and «Medication compliance scale¼. RESULTS: Patient in treatment group showed significantly better results than the control group in medication compliance scale assessment (p<0.001). The rate of readmissions was significantly higher in the control group than in the psychoeducation group (p=0.02). CONCLUSION: Brief psychoeducation for inpatients with FEP and emergency hospitalizations has beneficial effect on patients' compliance.

Impact of COVID-19 pandemic on anxiety, depression and distress - online survey results amid the pandemic in Russia.

Background: In 2020, the COVID-19 pandemic evoked a variety of research into the virus and its effects on mental health. A variety of mental health and psychological problems have been reported: stress, anxiety, depressive symptoms, insomnia, denial, stigma, anger and fear. Objectives: To assess the level of anxiety, depression and distress in the general population during the lockdown in Russia and to reveal factors associated with distress. Methods: An online survey was carried out from 22-27 April 2020 (the fourth week of lockdown) among the general population (mostly Moscow residents). The survey questions covered general information about people's social and demographic characteristics, experience of COVID-19, health condition (physical and mental), attitudes and views on the pandemic, and the need for psychological support. The survey included the Hospital Anxiety and Depression Scale (HADS) and evaluation of the preceding week's subjective distress level using a visual numeric scale (from 0 to 10). We also asked respondents to specify the causes of distress, adopted from the WHO information sheet relating to the major psychological challenges of the COVID-19 pandemic. Results: In total, 352 responses were collected (men = 74, women = 278; age (M ± SD) = 36.81 ± 11.36 y.o.).Most respondents (n = 225, 63.92%) did not have any personal experience of the coronavirus infection. Normal levels of anxiety and depression scores were prevalent in the sample. Higher than normal levels of HADS anxiety/depression ( 7 scores) were observed in 105 (29.83%) and 59 (16.76%) respondents, respectively; mean (95% CI)scores for HADS anxiety/depression were 6.23 [5.77, 6.68] /4.65 [4.22, 5.08] (women) and 4.20 [3.32, 5.09] /3.46[2.63, 4.29] (men), respectively.The leading causes of distress were: 1) the risk of financial problems in the future (n = 267, 76.3%); 2) violation of plans and the disruption to normal life (n = 235, 67.1%; and n = 240, 68.6%, respectively); 3) the health of elderly or chronically diseased relatives (n = 205, 58.6%) and 4) being in self-isolation (n = 186, 53.1%). Conclusion: The level of anxiety and depression during the COVID-19 pandemic in the study sample did not exceed the norm for the population in non-pandemic conditions. Our assessment of distress levels captured existing emotional problems, and distress levels were found to be connected with the reported need for psychological support.

[Insulin secretion by isolated rat pancreas as affected by prooxidants; relationship to glutathione release]. / Sekretsiia insulina izolirovannoi podzheludochnoi zhelezoi krys pri deistvii prooksidantov; sviaz' s vysvobozhdeniem glutationa.

Rates of basal and glucose-stimulated insulin and glutathione secretion were studied in experiments with isolated rat pancreas, as were prooxidant effects on these values. The rate of oxidized and recovered glutathione release was found increased at glucose concentration increase to 16.7 mmoles in perfusion solution. Addition of prooxidants (tert-butyl hydroperoxide and Fe2+) in concentrations 10(-4) mole did not change basal insulin secretion but resulted in reduction of glucose-stimulated hormone release. Under such conditions a reduction of the rate of oxidized and recovered glutathione release by the pancreas was observed which was adequate to changed GSH/GSSG ratio in isolated Langerhans' islets. It may be supposed that lipid peroxidation results in changed thiol-disulfide ratio in Langerhans' islets B cells and in reduction of their sensitivity to secretogen effect.