ABSTRACT
The cytokine blood profile in patients with complicated erysipelas was investigated. It was found that in patients with complications of erysipelas (gangrene, phlegmon, abscess, thrombophlebitis of the subcutaneous veins of the shin) levels of pro-inflammatory cytokines IL-1ß, TNF-α, IL-2, IL-6 in serum significantly increase and level of anti-inflammatory cytokine IL-4 increases slightly, as well as was found a significant increase in coefficients reflecting the ratio of pro-inflammatory and anti-inflammatory cytokines, which indicates the prevalence in the blood of examined patients with complications of erysipelas an anti-inflammatory properties. A more significant increase in pro-inflammatory cytokines serum levels is typical for patients with destructive forms of erysipelas - phlegmonous and gangrenous, a slight increase - for patients without purulent-necrotic component of complication (thrombophlebitis of the subcutaneous veins of the shin). In the future we plan to study pharmacological correction of shifts in cytokine blood profile with drugs with immunomodulating properties in patients with complicated erysipelas.
Subject(s)
Abscess/blood , Cellulitis/blood , Erysipelas/blood , Gangrene/blood , Thrombophlebitis/blood , Abscess/complications , Abscess/drug therapy , Abscess/immunology , Adult , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Biomarkers/blood , Cellulitis/complications , Cellulitis/drug therapy , Cellulitis/immunology , Erysipelas/complications , Erysipelas/drug therapy , Erysipelas/immunology , Female , Gangrene/complications , Gangrene/drug therapy , Gangrene/immunology , Humans , Interleukin-1beta/blood , Interleukin-1beta/immunology , Interleukin-2/blood , Interleukin-2/immunology , Interleukin-4/blood , Interleukin-4/immunology , Interleukin-6/blood , Interleukin-6/immunology , Male , Middle Aged , Thrombophlebitis/complications , Thrombophlebitis/drug therapy , Thrombophlebitis/immunology , Tumor Necrosis Factor-alpha/blood , Tumor Necrosis Factor-alpha/immunologyABSTRACT
The authors studied the effect of a dry protein mixture on the clinical course and protein and pigmentary metabolism, functional tests of the liver in 223 patients with viral hepatitis. It was found that this mixture favours reduction of the icteric period, more rapid restoration of the liver function and improves prognosis. The dry protein mixture is recommended to be included in dietotherapy of patients with viral hepatitis.