ABSTRACT
Multiple-day distraction regenerate contains a number of foci or zones merging into one another with different structural organization of the fibrocellular basis that reflects successive stages of reparative regeneration. At the moment of the last traction, the central part of the regenerate represents a zone of fibrogenesis (growth zone), which is common for the proximal and distal parts of the distraction regenerate. The other zones are paired and symmetrical: zones of angiogenesis, fibrous osteogenesis (primary), and osteogenesis (secondary). The latter include subzones of resorption, secondary osteogenesis, and functional remodeling.
Subject(s)
Bone Regeneration/physiology , Osteogenesis/physiology , Animals , Cell-Matrix Junctions/metabolism , Cell-Matrix Junctions/physiology , Microscopy, Atomic Force , Osteoblasts/metabolism , Osteoblasts/ultrastructure , Osteogenesis, Distraction , SheepABSTRACT
Fragmented embryonic bone tissue stimulates bone regeneration. Bone formation starts not from implanted embryonic fragments, but in intact periosteum and endosteum containing cambial cells of the osteodifferon. In rabbits, recovery of damaged radial bone after implantation of fragmented embryonic bone tissue into bone defect was associated with a pronounced periosteal reaction and focal resorption of intact ulnar bone. Consolidation of damaged radial bone without implantation of fragmented embryonic bone tissue was incomplete in all experimental animals.
