ABSTRACT
Changes in the microfloral species quality and quantity, blurring of the ecological niche, reduction or disappearance of lacto- and bifidobacteria, emergence of opportunistic and saprogenic flora were found in the intestine of patients with intestinal chronic renal failure. These findings are indicative of microecological abnormalities in the above patients.
Subject(s)
Hypertension/microbiology , Intestines/microbiology , Kidney Failure, Chronic/microbiology , Adult , Bacterial Infections/microbiology , Chronic Disease , Ecology , Feces/microbiology , Humans , Intestinal Diseases/microbiology , SyndromeABSTRACT
Data are reported on intestinal mechanisms of protein metabolism in renal failure in patients and experimental animals. These disorders are characterized by inhibition of the intestinal absorption capacities, disturbances of intestinal mechanisms of the amino acid kinetics and they develop along with a reduction of the total excretory renal function.
Subject(s)
Intestines/physiopathology , Kidney Failure, Chronic/physiopathology , Proteins/metabolism , Adult , Animals , Humans , Intestinal Absorption , Nephrectomy , Rats , Rats, Wistar , Serum Albumin, Radio-Iodinated , Time FactorsABSTRACT
The data on impairment of the intestinal mechanisms in 103 patients with chronic renal failure are presented. This impairment is characterized by inhibition of the absorption capacity of the intestine, an increase of the concentration of urea and creatinine in its contents, and by dysbacteriosis.
Subject(s)
Intestinal Diseases/etiology , Kidney Failure, Chronic/complications , Adult , Creatinine/analysis , Feces/chemistry , Feces/microbiology , Female , Humans , Intestinal Absorption , Intestinal Diseases/diagnostic imaging , Intestinal Diseases/microbiology , Intestinal Diseases/physiopathology , Intestines/diagnostic imaging , Intestines/microbiology , Kidney Failure, Chronic/diagnostic imaging , Kidney Failure, Chronic/microbiology , Kidney Failure, Chronic/physiopathology , Male , Radionuclide Imaging , Serum Albumin, Radio-Iodinated , Urea/analysisABSTRACT
Radioactive albumin studies were performed in patients with chronic renal disorders. The findings evidence an essential decline of intestinal protein-transport function, enhanced catabolism, impairment of protein synthesis and its renal loss which underlie protein deficiency.
Subject(s)
Albumins/metabolism , Intestinal Mucosa/metabolism , Kidney Diseases/metabolism , Adult , Biological Transport , Chronic Disease , Humans , Intestinal Absorption , Intestines/diagnostic imaging , Kidney Diseases/diagnostic imaging , Radionuclide Imaging , Scintillation Counting/instrumentation , Scintillation Counting/methods , Serum Albumin, Radio-Iodinated , Time FactorsABSTRACT
The presented results of studying, morphofunctional disturbances of the gastrointestinal tract in patients with chronic renal failure revealed a myxedema, decreased hydrolytic and transport activity, increased elimination of nitrogen substances into the gastrointestinal lumen, replacement of obligate microflora by pathogenic bacterial associations, as well as a system of morphologic changes in gastrointestinal mucosa, ultrastructural abnormalities of enterocytes and their compounds.
Subject(s)
Digestive System/physiopathology , Kidney Failure, Chronic/physiopathology , Animals , Creatinine/blood , Digestive System/microbiology , Dogs , Feces/microbiology , Humans , Intestinal Absorption/physiology , Intestinal Mucosa/physiopathology , Intestinal Mucosa/ultrastructure , Intestine, Small/physiopathology , Intestine, Small/ultrastructure , Kidney Failure, Chronic/etiology , Kidney Failure, Chronic/microbiology , RatsABSTRACT
Morphological changes in the organs of the gastrointestinal tract are caused by renal failure. They are reflected more in the small intestine and are accompanied by disturbance of the absorption process. The basis of these disorders are changes of the histoarchitecture of the absorbing surface of the small intestine.
Subject(s)
Digestive System/pathology , Kidney Failure, Chronic/pathology , Animals , Dogs , Kidney Failure, Chronic/etiology , Microscopy, Electron , Microscopy, Electron, Scanning , Rats , Rats, Inbred Strains , Time FactorsABSTRACT
The effect of intestinal microflora on the abdominal clinical signs was studied in patients with chronic diseases of the kidneys. Renal diseases are accompanied by morphological changes of digestive tract and by dysbacteriosis which may lead the clinical picture. The importance of these findings for the treatment of patients with renal diseases is emphasized.