Peculiarities of the distribution of man-made radionuclides in several European seas.

Results of a study on the distribution of the man-made radionuclides 137Cs and 90Sr in the surface waters of several European seas are presented. Based on an analysis of the ratio of these two radionuclides, an attempt was made to isolate the 'Chernobyl water' and to estimate the contribution of 'Chernobyl radioactivity' to the total radioactivity in the waters of the seas investigated.

[Morphologic manifestations of intercellular interaction in the organs of immunogenesis]. / Morfologicheskoe proiavlenie mezhkletochnogo vzaimodeistviia v organakh immunogeneza.

The morphological manifestations of intercellular contacts in guinea-pigs after the subcutaneous injection of 0.1 mg of BCG culture were studied by transmission and scanning electron microscopy. The morphological links between T-cells and B-lymphocytes, between B-lymphocytes and macrophages, as well as among individual macrophages were revealed. The intercellular links were shown to have different morphological manifestations depending on the type of cells and their localization in the organ. Thus, in the capillary lumen and the thymus cavity the formation of cytoplasmic bridges between the above-mentioned cells was revealed; in the stroma of the organ the formation of linking structures, similar to closing plates, between lymphocytes was observed. An increase in the number of micropinocytosis bubbles in the contact zone indicated the increased permeability of the cytoplasmic membrane and the intensified exchange processes between the cells.

[Immunohistochemical study of the accumulation of antibody-forming cells in the lungs following intrapulmonary and subcutaneous administration of apneumotropic antigen]. / Immunogistokhimicheskoe izuchenie nakopleniia antiteloobrazuiushchikh kletok v legkikh pri vnutrilegochnom i podkozhnom vvedenii apnevmotropnogo antigena.

Accumulation of the antibody-synthesizing cells in the lungs of guinea pigs in intratracheal and subcutaneous immunization was studied on a model of a complete typhoid bacilli antigen by means of Coons' method. Antibody-forming cells located in the interalveolar septi and in the peribronchial and perivascular connective tissue appeared with both method of the apneumotropic antigen administration. More of these cells accumulated in intrapulmonary application of the antigen. Repeated immunization by any method also led to the increase of their amount. The problem on the role played by the lungs in the immunogenesis is discussed.

[Experimental morphological study of the vaccination process following aerosol application of lyophilized live influenza A2/Hong Kong and B/USSR vaccines]. / Eksperimental'no-morfologicheskoe issledovanie vaktsinnogo protsessa pri aérozol'nom primenenii zhivykh sukhikh protivogrippoznikh vaktsii tipa A2/Honkong i B/SSSR

A comparative study of immunologic, immunomorphological and morphological responses of the viscera of white rats immunized by aerosol intranasally with lyophilized influenza A2/Hong Kong and B/USSR vaccines with an adjuvant (typhoid antigen) and without it was carried out. Also lung tissues were examined for intracellular inclusions considered to be a morphological indication of influenza virus implantation. No pathological lesions were found in the organs of the immunized animals. It is concluded that the intensity of immunologic and immuno-morphological responses depends upon the method of vaccine application and upon vaccine type but not upon the adjuvant.

[Participation of the lung in capturing subcutaneously injected antigens]. / Ob uchastii legkikh v zakhvate antigena pri podkozhnom vvedenii ego

Experiments were conducted on guinea pigs. With the aid of fluorescein-labeled antibodies it was shown that following a single or a two-fold immunization into the footpad complete typhoid antigen was revealed in the lung macrophages as soon as the first days (or after a two-fold administration-in several hours) and persisted there for 30 days. There was a tendency to concentration of the antigen-containing macrophages in the perivascular and the peribronchial tissues. The dynamics of the antigen spread along the lymphoid organs is also described.