ABSTRACT
In the early period after exposure to the radiation in the lethal dose (10 Gy) mice secreted with urine the volatile components, that attract for intact individuals. In the late period appear components with aversive property. In the terminal period after exposure to superlethal dose (70 Gy) dominate the secretions with aversive property. The exposure of intact recipients with the volatile secretions attractive or aversive in equal degree depression result in suppression their ability to the humoral immune response.
Subject(s)
Antibody Formation/radiation effects , Gamma Rays , Radiation Injuries, Experimental/immunology , Radiation Injuries, Experimental/urine , Sex Attractants/urine , Animals , Dose-Response Relationship, Radiation , Female , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Sexual Behavior, Animal/radiation effects , Volatilization , Whole-Body IrradiationABSTRACT
The influence of volatile urine chemosignals of irradiated (4 Gy) mice on the primary humoral immune response to sheep red blood cells in intact recipients was investigated. It was demonstrated that the direction of immunomodulatory effect is dependent upon the time at which the postradiation chemosignals was initially applied. The antibody response to antigen was markedly suppressed in mice that were exposed before antigen injection. When chemosignals applied immediately following inoculation of antigen the antibody response was unaffected. The immune response was increased when chemosignals was loadeded for 1-10 days after immunization. The possible mechanisms of immunomodulation are considered.
Subject(s)
Antibody Formation/radiation effects , Radiation Injuries, Experimental/immunology , Radiation Injuries, Experimental/urine , Smell/immunology , Thymus Gland/immunology , Animals , Antibodies/blood , Antibody-Producing Cells/immunology , Antibody-Producing Cells/radiation effects , Antigens/immunology , Erythrocytes/immunology , Gamma Rays , Immune Tolerance/drug effects , Immunization , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/blood , Sheep , Time Factors , VolatilizationSubject(s)
Behavior, Animal/physiology , Pheromones/physiology , Stress, Psychological/immunology , Stress, Psychological/pathology , Animals , Antibody-Producing Cells/immunology , Antibody-Producing Cells/pathology , Bone Marrow Cells/pathology , Bone Marrow Cells/physiology , Cell Proliferation , Chromosome Aberrations , Erythrocytes/immunology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Sheep , Smell , Species Specificity , Spleen/immunology , Spleen/pathologyABSTRACT
It was shown, that under physiological conditions, intact noninbred mice or high-inbred mice-testers in reaction of preference-avoidance prefer volatile components secreted by mice of a genetically identical group. After exposure to stress factors, mice release with urine the volatile components, which are more preferable by testers than the volatile secretion of intact mice indepedently of the genotype of mice.
Subject(s)
Odorants , Smell/physiology , Stress, Psychological/psychology , Animals , Escape Reaction/physiology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Stress, Psychological/urine , Time FactorsABSTRACT
It is shown that intact animals caged with stressed animals or in smell contact with natural secretions of stressed animals develop alterations of the immune system and peripheral blood cell composition. The decline in the genesis of antibodies to T-dependent antigen is related to the animals' gender and occurs at the height of poststress immunodepression.
Subject(s)
Stress, Psychological/blood , Stress, Psychological/immunology , Animals , Antibody Formation , Female , Leukocyte Count , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neutrophils/pathology , Organ Size , Rats , Rats, Wistar , Social Behavior , Thymus Gland/pathologyABSTRACT
Intact rats and mice were kept in one cage with irradiated rats and mice. Measurements of leukocyte and nuclear neutrophils counts in the peripheral blood, weight of the thymus and immune reactivity int he intact animals indicated that 1-2 weeks of sharing cage with irradiated animals produced a fall in the above values compared to those of the controls. This seems to be a reaction to changed behavior of the irradiated animals. The intact ones experienced anxiety which may provoke the above disorders.
Subject(s)
Adaptation, Physiological , Immune System/radiation effects , Radiation Injuries, Experimental , Animals , Female , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Rats , Rats, Wistar , Reference ValuesABSTRACT
It was showed that the daily transfer of natural secrets litter from irradiated mice to intact mice decreased parameters of intact mice immune reactivity in 14 days. Presumedly this effect, conditioned of pathological odours, discovered on one from mechanism of contact induction second immunodeficient, also caged intact with irradiated animals.
Subject(s)
Antibody Formation/immunology , Radiation Injuries, Experimental/immunology , Animals , Antibody-Producing Cells/immunology , Cobalt Radioisotopes/administration & dosage , Data Interpretation, Statistical , Erythrocytes/immunology , Feces , Female , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Dosage , Radiation Injuries, Experimental/urine , Sheep , Spleen/immunology , Time FactorsABSTRACT
It was shown, that sensitivity of immune response to stress in postirradiated period essentially depends from the dose of irradiation (1, 2 Gy) and the period after irradiation. The sensitivity was not distinguished from intact mice in early period further the sensitivity of immune response can be increased (1 Gy) or can be decreased (2 Gy), stress can be stimulated of the antibody-formation to sheep red blood cells in late period after irradiation.
Subject(s)
Antibody Formation/radiation effects , Radiation Injuries, Experimental/immunology , Stress, Physiological/immunology , Animals , Antibody Formation/immunology , Antibody-Producing Cells/immunology , Cobalt Radioisotopes/administration & dosage , Data Interpretation, Statistical , Erythrocytes/immunology , Female , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neutrophils/immunology , Radiation Dosage , Sheep , Spleen/immunologyABSTRACT
Rats and mice subjected to stress and/or irradiation or their urine induce impairment or the indices of immunologic reactivity in caged together their intact mates. It is suggested that communicative behavior, including olfactory-odor components, affect the state of blood and immunity systems.
Subject(s)
Behavior, Animal/physiology , Immune System Diseases/etiology , Animals , Behavior, Animal/radiation effects , Female , Immune System Diseases/physiopathology , Immune System Diseases/urine , Immunity, Cellular/physiology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neuroimmunomodulation/immunology , Neuroimmunomodulation/radiation effects , Rats , Rats, Wistar , Stress, Psychological/complications , Stress, Psychological/etiology , Stress, Psychological/physiopathology , Stress, Psychological/urine , SwimmingABSTRACT
Disturbances in humoral immune response to sheep erythrocytes after separate and combined effect of ionizing radiation (2 and 4 Gy) and stress (swimming for 10 of 60 min) was studied in mice. The increase in sensitivity to stress was found in irradiated mice. Superposition of undulating dynamics of post-stress immunosuppression on dynamics of post-radiation disorder was revealed. This is due to the different mechanisms of disturbances: redistribution of precursors of immunocompetent cells between immune organs in the first case and destruction of cells in the second case.
Subject(s)
Antibody Formation/radiation effects , Stress, Physiological/immunology , Whole-Body Irradiation/adverse effects , Animals , Antibody-Producing Cells/immunology , Antibody-Producing Cells/radiation effects , Dose-Response Relationship, Radiation , Female , Gamma Rays , Immunization , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Physical Exertion/radiation effects , Spleen/immunology , Spleen/radiation effects , Swimming , Time FactorsABSTRACT
A model for secondary postradiation immunodeficiency of mice has been used to compare immunocorrective activities of some new immunomodulators (arbidol, cagocel, myelopid, proleukinferon and fragmine) administered at late times (2-3 months) after exposure to a nonlethal radiation dose (4.0 Gy). The highest immunocorrective effect has been shown with fragmine and proleukinferon.
Subject(s)
Activins , Adjuvants, Immunologic/therapeutic use , Immunologic Deficiency Syndromes/therapy , Oligopeptides , Radiation Injuries, Experimental/complications , Animals , Antibody-Producing Cells/drug effects , Antibody-Producing Cells/immunology , Antibody-Producing Cells/radiation effects , Dalteparin/therapeutic use , Gossypol/analogs & derivatives , Gossypol/therapeutic use , Graft vs Host Reaction/drug effects , Graft vs Host Reaction/radiation effects , Immunity, Cellular/drug effects , Immunity, Cellular/radiation effects , Immunologic Deficiency Syndromes/etiology , Immunologic Deficiency Syndromes/immunology , Indoles/therapeutic use , Macrophages, Peritoneal/immunology , Male , Mice , Mice, Inbred CBA , Peptides/therapeutic use , Phagocytosis/drug effects , Phagocytosis/radiation effects , Radiation Injuries, Experimental/immunology , Time FactorsABSTRACT
The authors analyse their diagnostic and therapeutic experience with 26 patients suffering from congenital pulmonary arteriovenous aneurysms. Symptoms of the disease were found to depend directly on the presence and volume of arterial blood shunted into the venous bed. The volume of shunted nonoxygenated blood varied between 20 and 48 p.c.; the reflux caused hypoxic hypoxaemia with HbO2art. = 91.2 +/- 1.43%; pO2art. = 63.6 +/- 5.54 mmHg. Aimed tomography and pulmonary angiography proved most advantageous in terms of diagnostic; with their aid it was possible to identify three variants of congenital pulmonary arteriovenous aneurysm: isolated, multiple and "of the capillary haemangioma type".
Subject(s)
Arteriovenous Malformations/diagnostic imaging , Pulmonary Artery/abnormalities , Pulmonary Veins/abnormalities , Adolescent , Adult , Angiography , Arteriovenous Malformations/mortality , Arteriovenous Malformations/surgery , Female , Follow-Up Studies , Hemangioma/congenital , Hemangioma/diagnostic imaging , Hemangioma/mortality , Hemangioma/surgery , Hemodynamics/physiology , Humans , Lung Neoplasms/congenital , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/mortality , Lung Neoplasms/surgery , Male , Middle Aged , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/surgery , Pulmonary Veins/diagnostic imaging , Pulmonary Veins/surgeryABSTRACT
The authors have analyzed results of the surgical treatment of 24 out of 26 patients observed at the clinic for arterio-venous aneurysms of the lungs. It was found that the reduction of efficiency of the gas exchange function of the lungs before operation manifested itself by arterial and venous hypoxemia with an increased arterio-venous oxygen difference and pronounced decrease of blood oxygen strain. Good results of the operative treatment, rapid recovery of blood oxygenation, disappearance of hypoxemia symptoms make the surgical method the only radical one in treatment of such patients. The operation of choice was lobectomy. No lethal outcomes followed.
