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Eksp Klin Farmakol ; 62(2): 3-6, 1999.
Article in Russian | MEDLINE | ID: mdl-10340117

ABSTRACT

Bromantan [N-2-(para-(bromphenyl)-N-2-(aminoadamantan)] possesses psychostimulating activity in experiments on animals. With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect. Bromantan is characterized by a positive effect on mnemonic processes and on obtaining the results of complex operant activity in rats.


Subject(s)
Amantadine/analogs & derivatives , Psychotropic Drugs/pharmacology , Amantadine/pharmacology , Amantadine/toxicity , Animals , Behavior, Animal/drug effects , Catalepsy/chemically induced , Dose-Response Relationship, Drug , Electric Stimulation , Electroencephalography/drug effects , Lethal Dose 50 , Male , Mice , Motor Activity/drug effects , Psychotropic Drugs/toxicity , Rabbits , Rats , Time Factors
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