Pharmacological activities of Grewia bicolor roots.

Intraperitoneal administration of the ethanol extract of Grewia bicolor root (300 mg/kg) to rats in early pregnancy (+1-4 days) did not affect the number of conception sites, but significantly increased resorption. In late pregnancy (+19-20 days), the extract (300 mg/kg) did not affect duration of the gestation period; however, 400 mg/kg was lethal to all mother rats. The active compound, apparently a peptide, exerted a serotonin-like effect on rat uterus, rat fundus and rabbit jejunum. All these effects were abolished by methysergide. A transient serotonin-like rise in cat blood pressure was produced by the active fraction and this effect was also blocked by cyproheptadine.

Toxicity of chlorpyrifos in Nubian goats.

A single oral administration of chlorpyrifos to Nubian goats at 1200, 600 and 300 mg/kg caused nervous signs and death within 15 minutes to 2 days of treatment. An oral dose of the compound at 150 mg/kg was toxic, but not fatal to goats. Animals given chlorpyrifos orally at daily doses of 300, 150 and 75 mg/kg showed signs of toxicity and died within 2 to 7 days of treatment. Pathological, biochemical and haematological changes are described.

Synthesis and pharmacological effect of substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides.

Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed.