ABSTRACT
The influence of homolymph and of that incubated with chemopreparations on in vitro activity of antioxidants of blood was compared to establish a possible mechanism of effective application of homolymphochemotherapy for locally advanced tumors of the lung. As a result of homolymph injection into the blood, mainly non-enzymatic systems of antioxidant defense by lymphocytes were affected. This was probably due to their being disposed of in the course of host-against-transplant reaction to heterogenous antigens of donor lymph. Neutrophil functional activity was shown to pick up again as homolymph and chemotherapeutic drugs interacted with blood. A possible therapeutic effect of homolymph and chemopreparations on blood may be alleviating lung tumor suppression of granulocytes.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antioxidants/metabolism , Immunotherapy/methods , Lung Neoplasms/drug therapy , Lung Neoplasms/immunology , Lymph/immunology , Neutrophils/drug effects , Neutrophils/immunology , Adult , Combined Modality Therapy , Humans , Injections , Middle Aged , Transplantation, HomologousABSTRACT
To establish the effect of autolymphochemotherapy on enzymatic and non-enzymatic systems of antioxidant protection of plasma and formed elements in blood of lung cancer patients, certain indices of peroxidation processes were simulated using a model containing blood and autolymph (with chemopreparations) sampled from patients with lung tumors. Autolymph injection into the patients' blood stream was followed on the basis moderate stress reaction which of caused reactions of endogenous antioxidants to oscillate. However, the structure and function of cellular membranes of formed elements were not affected. Chemotherapy neither aggravated stress condition nor did it exert direct cytotoxic effect on blood cells.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/pharmacology , Antioxidants/metabolism , Blood/drug effects , Immunotherapy/methods , Lung Neoplasms/drug therapy , Lung Neoplasms/immunology , Lymph/immunology , Adult , Blood Cells/drug effects , Humans , Injections , Lung Neoplasms/blood , Middle Aged , Oxidation-Reduction/drug effects , Plasma/drug effects , Transplantation, AutologousABSTRACT
Indices of lipid peroxidation in lymph from lung cancer patients before and after chemotherapy were studied. Chemotherapeutic drugs were shown to exert a moderate stressor effect on lymph by triggering oscillating reactions of endogenous antioxidant systems. Stress releases a pool of low-molecular weight antioxidants. Absence of catalase activity in plasma and lymphocytes is a peculiar feature of lymph in lung cancer patients.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/pharmacology , Free Radicals , Lipid Peroxidation/drug effects , Lung Neoplasms/metabolism , Lymph/metabolism , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , Humans , Lung Neoplasms/drug therapy , Male , Middle AgedSubject(s)
Fibrosarcoma/epidemiology , Hemangiosarcoma/epidemiology , Leiomyosarcoma/epidemiology , Lung Neoplasms/epidemiology , Adolescent , Adult , Female , Fibrosarcoma/pathology , Hemangiosarcoma/pathology , Humans , Leiomyosarcoma/pathology , Lung Neoplasms/pathology , Male , Middle Aged , Retrospective Studies , Russia/epidemiologyABSTRACT
A relatively more favorable course of lung cancer and higher survival rates observed in female patients than in males make the case for further study of the problem. Endocrine system study group included female lung cancer patients. Blood-ACTH, FSH, LH, STH, T3 and T4 as well as F, 17-CS and estrogen excretion with urine were followed prior to, immediately and long after treatment in 25 menopausal and 11 premenopausal cases (at folliculin phase). Most patients revealed increased levels of free hydrocortisone in blood and urine matched by a lowered excretion of 17-CS. Hyperproduction of ACTH was registered in 40%, whereas 60% showed subnormal concentrations of said hormone. On the average, the levels of estrogens were increased, gonadotropin--decreased, T3--below normal concentrations and T4 and STH--within norm. TTH levels showed a wide-range variation: half that in healthy females-20%, and much higher than in healthy one-65%. Concentration of F was close to normal 15-20 days after surgery while ACTH and 17-CS--after one year. The levels of the other hormones remained virtually unchanged within 1-3 years.
Subject(s)
Adenocarcinoma/physiopathology , Carcinoma, Squamous Cell/physiopathology , Hormones/blood , Lung Neoplasms/physiopathology , Adenocarcinoma/therapy , Carcinoma, Squamous Cell/therapy , Combined Modality Therapy , Female , Humans , Lung Neoplasms/therapy , Male , Menopause , Middle Aged , Prognosis , Sex Factors , Time FactorsABSTRACT
The results of studying the steroid hormones excretion in 90 patients with lung squamous-cell cancer under chemo-radiation therapy are reported. It is shown that an effective treatment is associated with certain changes in the excretion of androsterone, 11 OH 17KS, estradiol, cortisol and pregnanediol.
Subject(s)
17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Carcinoma, Squamous Cell/therapy , Estrogens/urine , Lung Neoplasms/therapy , Adult , Aged , Carcinoma, Squamous Cell/urine , Evaluation Studies as Topic , Follow-Up Studies , Humans , Lung Neoplasms/urine , Male , Middle AgedABSTRACT
Following the termination of chemoradiation therapy of patients with lung cancer a decreased level of 17-OCS and 17-KS with the urine is observed. A combination of chemoradiation therapy with testosterone-propionate or prednisolone renders a stabilizing effect on the level of corticosteroids excretion. Chemoradiation therapy, used simultabolism. The application of the hormones involved lessens the number of complications during chemoradiation therapy and increases the survival rate in these patients.
