[Metabolism of several blood prostaglandins in patients with angina pectoris during helium-neon laser therapy]. / Metabolizm nekotorykh prostaglandinov krovi u bol'nykh so stenokardiei na fone gelii-neonovoi lazernoi terapii.

The paper shows the high therapeutical efficiency of combined He-Ne laser therapy in patients with coronary heart disease. Its effect on the thromboxane-prostacyclin system is one of the mechanisms of laser impact. The combined He-Ne laser therapy promotes normalization of the level of thromboxane B2 and its ratio to the metabolite prostacyclin.

[A comparative evaluation of the biochemical and psychopathological characteristics in subjects with signs of pedophilia]. / Sravnitel'naia otsenka biokhimicheskikh i psikhopatologicheskikh kharakteristik u lits s priznakami pedofilii.

RIA was employed to examine 54 test subjects who committed sexual crimes with regard to children of tender age. A syndrome of sexual perversions in the form of pedophilia was discovered in 42 persons. Different patients' groups manifested significant differences in the content of hypophyseal and sexual hormones in the blood serum. A significant lowering of testosterone was revealed in persons with heterosexual pedophilia and with pedophilia without any aggressive and sadistic disorders. They also demonstrated a high prolactin content.

[Combined helium-neon laser therapy in patients with ischemic heart disease]. / Kombinirovannaia gelii-neon-lazernaia terapiia u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper describes the combined helium-neon-laser (HNL) therapy (intravenous and topical) developed by the authors to treat patients with coronary heart disease. A high efficacy of this therapy mode was demonstrated in patients over 70 years of age with Functional Classes III-IV angina refractory to antianginal agents. The mechanisms responsible for therapeutic efficiency of laser irradiation were studied at the membraneous and cellular levels. There is evidence that the combined HNL-therapy had advantages over topical HNL exposure in terms of higher clinical efficiency and patterns of abnormal chemical changes.

[Prevention of the "secondary exacerbation" phenomenon in patients with stenocardia treated with helium-neon laser therapy]. / Profilaktika fenomena "vtorichnogo obostreniia" u bol'nykh stenokardiei pri gelii-neon-lazernoi terapii.

The authors have developed a method for the prevention of angina pectoris "'secondary exacerbation' developing during He-Ne laser irradiation of the Zakharyin-Head skin sites. Intake of aevit (a multivitamin preparation) in a daily dose of 600 mg allows increasing the length of exposure to He-Ne laser in the most grave coronary cases and prolongs the remission. A rationale for He-Ne laser therapy efficacy combined with aevit is given.

[Clinico-pathochemical substantiation of the exacerbation phenomenon in patients with ischemic heart disease during treatment with the helium-neon laser]. / Kliniko-patokhimicheskoe obosnovanie fenomena obostreniia u bol'nykh ishemicheskoi bolezn'iu serdtsa pri lechenii gelii-neonovym lazerom.

Some pathochemical mechanisms of coronary disease aggravation in the course of laser therapy were assessed by means of the measurement of erythrocyte membrane lipids and phospholipids as well as plasma alpha-tocopherol and diene conjugate levels. The aggravation was associated with an activation of metabolic processes aiming to produce regeneration of membrane structures. The regeneration takes place in the presence of chronic deficiency of total phospholipids and inadequate antioxidant protection of biomembranes, therefore complete stabilization and normalization of their composition and activity is impossible.

[Clinico-biochemical parallels against a background of traditional treatment and laser therapy of patients with ischemic heart disease]. / Kliniko-biokhimicheskie paralleli na fone traditsionnogo lecheniia i lazeroterapii bol'nykh ishemicheskoi bolezn'iu serdtsa.

The paper is devoted to analysis of clinico-biochemical indices and a quest for additional pathologico-chemical criteria at the cell membrane level of the efficacy of helium-neon laser therapy in coronary heart disease (CHD). Another task was to decipher a number of metabolic signs of the phenomenon of CHD "exacerbation" in laser therapy (during 4-6 sessions). Positive clinical results were obtained in 98% of the patients. A favorable time course was noted in serum lipoprotein spectrum indices and in lipid and phospholipid structure of erythrocyte membranes. Laser therapy caused mobilization of the cell membrane antioxidant defense. The 4th-6th session of irradiation was marked by temporary clinical deterioration--"exacerbation" of disease accompanied by an increase in the level of erythrocyte total phospholipids (at the expense of PTEA), a decrease in free fatty acid deficiency against a background of advancing alpha-tocopherol deficiency and a rise of the blood level of lipid peroxidation primary products (diene conjugates). A conclusion was that membrane protective drugs and drugs enhancing cell energy and antioxidant defense resources promoting the "deactivation" of influence on the membrane of lipid peroxidation metabolites (tocopherol, Essentiale, retinol, etc.) should be incorporated in therapy of CHD in order to prevent the phenomenon of its "exacerbation".