Dissipativity-based non-fragile sampled-data control design of interval type-2 fuzzy systems subject to random delays.

This paper investigates the ß-dissipativity-based reliable non-fragile sampled-data control problem for a class of interval type-2 (IT2) fuzzy systems. In particular, it is allowed to have randomly occurring time-varying delays in the controller design, which are modeled by Bernoulli distributed white noise sequences. Precisely, the IT2 fuzzy model and the non-fragile sampled-data controller are formulated by considering the mismatched membership functions. By constructing an appropriate Lyapunov-Krasovskii functional, a set of delay-dependent conditions is derived to guarantee that the closed-loop IT2 fuzzy system is strictly -ß-dissipative. Moreover, the gain matrices of feedback reliable non-fragile sampled-data controller are derived in terms of linear matrix inequalities (LMIs), which can be solved by using existing LMI solvers. Two numerical examples are eventually given to illustrate the applicability and effectiveness of the proposed controller design technique.

Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers.

AIM: In order to improve the delivery of aromatic drugs by micellar assemblies, and particularly by long and flexible filomicelles, aromatic groups were integrated into the hydrophobic block of a degradable diblock copolymer. MATERIALS & METHODS: Aromatic filomicelles were formed by self-directed assembly of amphiphilic diblock copolymer PEG-PBCL with suitable block ratios. Worm-like filomicelles with an aromatic core were loaded with a common chemotherapeutic, Paclitaxel, for tests of release as well as effects on cancer cell lines in vitro and in vivo. RESULTS: Aromatic filomicelles loaded more Paclitaxel than analogous aliphatic systems. Cell death and aneuploidy of surviving cells (which indicates toxicity) were highest for carcinoma lines treated in vitro with the new filomicelles. Initial tests in vivo also suggest more potent tumor shrinkage. CONCLUSION: Flexible filomicelles with an aromatic core form an efficient drug delivery system that leads to higher cell death than previously reported systems, while inducing aneuploidy in surviving cells.