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1.
Springerplus ; 2: 657, 2013.
Article in English | MEDLINE | ID: mdl-24349959

ABSTRACT

N-acetylglucosaminyltransferase V (GnT-V), an enzyme with a key role in the branching of asparagine-linked oligosaccharides, is strongly linked to tumor invasion and metastasis of many solid tumors. Here we searched for correlations between the clinical features of patients with oral squamous cell carcinoma (OSCC) and GnT-V expression in the tumor, and we studied the feasibility of using GnT-V as a marker for oral cancer prognosis. Samples from 68 patients with OSCC were examined by immunohistochemistry using antibodies against GnT-V. Correlations between the expression level of GnT-V in the tumor and patient clinical features were statistically analyzed. Positive GnT-V expression was found in 48 cases (70.6%), and negative GnT-V expression was found in 20 cases (29.4%). Negative GnT-V expression was associated with mode of invasion by multiple logistic regression analysis (OR: 3.605; P = 0.048). Biological characteristics of tumors and the Ki-67 labeling index were higher in tumors with negative GnT-V expression than in those with positive GnT-V expression, although the difference was not significant (P = 0.176). Patients with negative GnT-V expression had significantly shorter survival than those with tumors having positive GnT-V expression (5-year survival rate, 58.2% and 86.5%, respectively; P = 0.025). Negative GnT-V expression was a significant unfavorable prognostic factor for OSCC (hazard ratio, 4.246; P = 0.045). The loss of GnT-V expression is a likely indicator of tumors with high potential of tumor invasion and poor prognosis in OSCC patients.

2.
J Craniofac Surg ; 23(6): 1596-601, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23147280

ABSTRACT

We evaluated the effects of presurgical nasoalveolar molding (NAM) with an orthopedic appliance and compared them with a passive orthopedic method (Hotz plate, HP), focusing on the naris morphology and width of the alveolar and palate cleft gap. The subjects were 28 unilateral complete cleft lip and palate patients treated with primary cheiloplasty at Tsukuba University Hospital from 2004 to 2011. Thirteen patients were treated preoperatively with NAM (NAM group), and 15 with HP (HP group). The surgical outcome was assessed according to left-right naris symmetry, as measured by the area ratio, perimeter ratio, aspect a/u ratio (aspect ratio of the affected side/aspect ratio of the unaffected side), and Hausdorff distance. In addition, the alveolar and palate cleft width was measured at the times of orthopedic plate setting and primary cheiloplasty. The aspect ratio was significantly smaller in the NAM group than in the HP group before the operation. In both groups, the aspect ratio, perimeter ratio, and Hausdorff distance were significantly smaller after the operation than before. The width of the alveolar and palate cleft gap was significantly narrowed in the NAM group, and the cleft gap at the initiation of NAM correlated significantly with the Hausdorff distance after cheiloplasty. We found that NAM improved the form of the naris after primary cheiloplasty and decreased the palate cleft gap more effectively than HP and that the width of the palate cleft gap was correlated with the surgical outcome of the naris.


Subject(s)
Alveolar Process/abnormalities , Cleft Lip/therapy , Cleft Palate/therapy , Nose/abnormalities , Orthopedic Procedures/instrumentation , Alveolar Process/surgery , Case-Control Studies , Cleft Lip/surgery , Cleft Palate/surgery , Female , Humans , Infant , Infant, Newborn , Male , Nose/surgery , Preoperative Care , Treatment Outcome
3.
Article in English | MEDLINE | ID: mdl-22906581

ABSTRACT

OBJECTIVE: To evaluate surgery results, we established a novel method to digitize nasal morphology with the use of Hausdorff distance and analyzed nose morphology after cheiloplasty. STUDY DESIGN: We evaluated the naris after primary cheiloplasty of 30 unilateral cleft lip and palate patients. Similarity between left and right sides was assessed by visual evaluation, area ratio, perimeter ratio, aspect a/u ratio, and Hausdorff distance. The postoperative naris morphology was also compared between 15 patients treated with a Hotz plate before surgery and 15 not treated. RESULTS: Significant correlation with visual evaluation was found for Hausdorff distance. For the groups with and without Hotz plate treatment, the visual evaluation was higher and Hausdorff distance significantly lower in the treated group. CONCLUSIONS: The morphologic measurement obtained using the Hausdorff distance was the closest to visual evaluation, and assessment using Hausdorff distance suggested that using a Hotz plate helps retain the symmetry of the nares after cheiloplasty.


Subject(s)
Cleft Lip/surgery , Cleft Palate/surgery , Orthopedic Procedures/methods , Humans
4.
Int J Oral Sci ; 4(3): 166-9, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22699262

ABSTRACT

Angiosarcoma is an uncommon malignancy, which spread out from the endothelial cells of vessels. Scalp angiosarcoma with cervical lymph node metastasis is particularly rare. This article describes a rare case of angiosarcoma of the scalp, presenting as neck inflammation. Imaging procedures such as computed tomography (CT), magnetic resonance image (MRI) and ultrasonography (US) were not sufficient to diagnose this case. A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis. Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion. Once the angiosarcoma diagnosis was confirmed histologically, sequential weekly and monthly docetaxel (DTX) treatment was effective in preventing reoccurrence. Nonetheless, the optimization of angiosarcoma treatment remains a future goal. Although patients generally describe pain and swelling at the primary lesion site, this patient complained only of painful neck inflammation, without any indication of pain or swelling of the scalp. A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp.


Subject(s)
Head and Neck Neoplasms/pathology , Hemangiosarcoma/pathology , Neck/pathology , Scalp/pathology , Skin Neoplasms/pathology , Aged , Antineoplastic Agents/therapeutic use , Cranial Irradiation , Docetaxel , Head and Neck Neoplasms/diagnostic imaging , Head and Neck Neoplasms/therapy , Hemangiosarcoma/diagnostic imaging , Hemangiosarcoma/therapy , Humans , Lymphatic Metastasis , Male , Positron-Emission Tomography , Radiography , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/therapy , Taxoids/therapeutic use , Ultrasonography
5.
Oral Maxillofac Surg ; 16(1): 65-8, 2012 Mar.
Article in English | MEDLINE | ID: mdl-20978812

ABSTRACT

BACKGROUND: Intraoral inflammatory pseudotumor (IPT) is a rare, benign non-neoplastic lesion that presents as a rapidly growing mass with aggressive behavior, which can be mistaken for a malignant process. CASE REPORT: This article presents a rare case of IPT of the mandible in a 70-year-old male patient. Examination of the oral cavity revealed a hemorrhagic soft mass of the mandibular region. The patient was treated with surgery. Histologic examination of the resected specimen showed proliferation of fascicular spindle cells and a dense, chronic inflammatory cell infiltrate consisting of neutrophils, eosinophils, and lymphocytes. Immunohistochemically, the spindle cells expressed vimentin, α smooth muscle actin, and CD68, indicating a diagnosis of IPT. DISCUSSION: IPT is an unusual benign pathology in the oral and maxillofacial area. Because of its aggressive clinical and radiological features, it can be mistaken for a malignancy. We suggest that oral and maxillofacial surgeons should be aware of the specific features of IPT to avoid unnecessary aggressive treatments such as a radical resection.


Subject(s)
Carcinoma, Squamous Cell/surgery , Granuloma, Plasma Cell/surgery , Mandibular Diseases/surgery , Neoplasm Recurrence, Local/surgery , Palatal Neoplasms/surgery , Palate, Soft/surgery , Aged , Carcinoma, Squamous Cell/diagnostic imaging , Carcinoma, Squamous Cell/pathology , Granuloma, Plasma Cell/diagnostic imaging , Granuloma, Plasma Cell/pathology , Humans , Image Interpretation, Computer-Assisted , Magnetic Resonance Imaging , Male , Mandible/pathology , Mandible/surgery , Mandibular Diseases/diagnostic imaging , Mandibular Diseases/pathology , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasm Recurrence, Local/pathology , Palatal Neoplasms/diagnostic imaging , Palatal Neoplasms/pathology , Palate, Soft/diagnostic imaging , Palate, Soft/pathology , Radiography, Panoramic , Tomography, X-Ray Computed
6.
Oral Maxillofac Surg ; 16(1): 111-4, 2012 Mar.
Article in English | MEDLINE | ID: mdl-21327332

ABSTRACT

BACKGROUND: Basal cell adenoma is a benign neoplasm of the salivary glands. This tumor usually arises in the major glands, with the parotid being the most frequent site of occurrence, while it is rare in the minor salivary glands. We report a case of basal cell adenoma of a minor salivary gland on the palate. CASE: The patient was a 68-year-old man. Intraoral examination revealed a mass measuring 20 × 20 mm that was elastic-hard, dark violet, non-ulcerated, and covered the normal mucosa. Computed tomography scan and magnetic resonance imaging (MRI) both showed a mass situated in front of the soft palate. The T1-weighted MRI revealed tumor isointensity, and the T2-weighted image showed tumor hyperintensity. The clinical diagnosis was palate tumor, and excision was performed under general anesthesia. Histopathological examination revealed that an encapsulated mass had grown under the epithelium and indicated a diagnosis of basal cell adenoma. DISCUSSION: Although no recurrence has been detected in the 3 years and 6 months of follow up, there was a case of malignant transformation of a basal cell adenoma reported. Therefore, careful follow-up observation will continue to be important.


Subject(s)
Adenoma/pathology , Palatal Neoplasms/pathology , Palate, Soft/pathology , Salivary Gland Neoplasms/pathology , Salivary Glands, Minor/pathology , Adenoma/surgery , Aged , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Neoplasm Staging , Palatal Neoplasms/surgery , Palate, Soft/surgery , Salivary Gland Neoplasms/surgery , Salivary Glands, Minor/surgery , Tomography, X-Ray Computed
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