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1.
Vopr Onkol ; 45(3): 241-4, 1999.
Article in Russian | MEDLINE | ID: mdl-10443223

ABSTRACT

The influence of homolymph and of that incubated with chemopreparations on in vitro activity of antioxidants of blood was compared to establish a possible mechanism of effective application of homolymphochemotherapy for locally advanced tumors of the lung. As a result of homolymph injection into the blood, mainly non-enzymatic systems of antioxidant defense by lymphocytes were affected. This was probably due to their being disposed of in the course of host-against-transplant reaction to heterogenous antigens of donor lymph. Neutrophil functional activity was shown to pick up again as homolymph and chemotherapeutic drugs interacted with blood. A possible therapeutic effect of homolymph and chemopreparations on blood may be alleviating lung tumor suppression of granulocytes.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antioxidants/metabolism , Immunotherapy/methods , Lung Neoplasms/drug therapy , Lung Neoplasms/immunology , Lymph/immunology , Neutrophils/drug effects , Neutrophils/immunology , Adult , Combined Modality Therapy , Humans , Injections , Middle Aged , Transplantation, Homologous
2.
Vopr Onkol ; 45(3): 245-8, 1999.
Article in Russian | MEDLINE | ID: mdl-10443224

ABSTRACT

To establish the effect of autolymphochemotherapy on enzymatic and non-enzymatic systems of antioxidant protection of plasma and formed elements in blood of lung cancer patients, certain indices of peroxidation processes were simulated using a model containing blood and autolymph (with chemopreparations) sampled from patients with lung tumors. Autolymph injection into the patients' blood stream was followed on the basis moderate stress reaction which of caused reactions of endogenous antioxidants to oscillate. However, the structure and function of cellular membranes of formed elements were not affected. Chemotherapy neither aggravated stress condition nor did it exert direct cytotoxic effect on blood cells.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/pharmacology , Antioxidants/metabolism , Blood/drug effects , Immunotherapy/methods , Lung Neoplasms/drug therapy , Lung Neoplasms/immunology , Lymph/immunology , Adult , Blood Cells/drug effects , Humans , Injections , Lung Neoplasms/blood , Middle Aged , Oxidation-Reduction/drug effects , Plasma/drug effects , Transplantation, Autologous
3.
Neirofiziologiia ; 16(1): 116-23, 1984.
Article in Russian | MEDLINE | ID: mdl-6717674

ABSTRACT

Dynamic and static properties of neurons were investigated in lateral suprasylvian area of cat. It was shown that neurons with different dynamic characteristics could have the receptive fields with similar static organization. Thus strict correlation between static and dynamic organization of the receptive fields of suprasylvian neurons were not observed. The majority of black-sensitive neurons appear to have off-fields. The contrast reversal test of moving stimuli revealed that the generation of responses both to the light and to the black stimuli was performed by the same part of the receptive field and was not conditioned by the spatially separate on- and off-discharge centers in the receptive field.


Subject(s)
Motion Perception/physiology , Visual Cortex/physiology , Animals , Brain Mapping , Cats , Light , Visual Cortex/cytology , Visual Fields
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