Continuous Monitoring of Interstitial Fluid Glucose Responses to Endurance Exercise with Different Levels of Carbohydrate Intake.

We compared the 24 h changes in interstitial fluid glucose concentration (IGC) following a simulated soccer match between subjects consuming a high-carbohydrate (HCHO; 8 g/kg BW/day) diet and those consuming a moderate-carbohydrate (MCHO; 4 g/kg BW/day) diet. Eight active healthy males participated in two different trials. The subjects were provided with the prescribed diets from days 1 to 3. On day 3, the subjects performed 90 min (2 bouts × 45 min) of exercise simulating a soccer match. The IGC of the upper arm was continuously monitored from days 1 to 4. No significant difference in the IGC was observed between trials during exercise. The total area under the curve (t-AUC) value during exercise did not significantly differ between the HCHO (9719 ± 305 mg/dL·90 min) and MCHO (9991 ± 140 mg/dL·90 min). Serum total ketone body and beta-hydroxybutyrate concentrations were significantly higher in the MCHO than in the HCHO after a second bout of exercise. No significant differences in the IGC were observed between trials at any time point during the night after exercise (0:00-7:00). In addition, t-AUC value during the night did not significantly differ between the HCHO (32,378 ± 873 mg/dL·420 min) and MCHO (31,749 ± 633 mg/dL·420 min). In conclusion, two days of consuming different carbohydrate intake levels did not significantly affect the IGC during a 90 min simulated soccer match. Moreover, the IGC during the night following the exercise did not significantly differ between the two trials despite the different carbohydrate intake levels (8 vs. 4 g/kg BW/day).

Zircon U-Pb chronology on plutonic rocks from northeastern Cambodia.

Zircon U-Pb geochronology was carried out on plutonic rocks from Phnom Daek, Phnom Koy Rmeas, Svay Chras, Kon Mom, Koh Nheak, Andong Meas, Oyadav South, Svay Leu, and Phnom Soporkaley. The zircon U-Pb ages from the plutonic rocks determined in this study can be roughly divided into two groups. One is the Late Permian to Triassic ages of 278-202 Ma for the Phnom Daek, Phnom Koy Rmeas, Oyadav South, Svay Leu, and Phnom Soporkaley, and the other is the early Cretaceous ages of 118-98 Ma for the Svay Chras, Kon Mom, Koh Nheak, and Andong Meas samples. The plutonic rocks from Phnom Daek, Phnom Koy Rmeas, Svay Leu, Oyadav South, and Phnom Soporkaley were likely formed by magmatic activity in the Loei Fold Belt. These plutonic rocks were likely formed in an extensional setting and/or a region where the continental crust was thin. The plutonic rocks of Svay Chras, Kon Mom, Koh Nheak, and Andong Meas were likely formed by magmatic activity in the Dalat-Kratie Fold Belt, related to the NW-directed subduction of the Paleo-Pacific Ocean plate. These plutonic rocks are thought to correspond to the Dinhquan suite in southern Vietnam. The Kon Mom and Koh Nheak plutonic rocks fall within the alkaline series, which suggests that the magma genesis was deep and far from the western Paleo-Pacific Ocean plate. Magmatic activity in the Dalat-Kratie Fold Belt migrated oceanward as a whole during the Cretaceous.

Aortic intramural hematoma associated with metastatic carcinoma.

We present a case of aortic intramural hematoma, a variant of aortic dissection, with metastatic carcinoma invasion within the aortic wall and pseudolumen. An elderly male patient with a history of controlled hypertension initially experienced chest pain. A computed tomographic scan revealed aortic intramural hematoma; thus, conservative therapy was performed. One and a half months later, tumors in both adrenal glands and the lumbar vertebra were discovered. The primary site was not identified, and the patient died following septic shock 1 month later. An autopsy revealed intramural hematoma throughout the aorta, as well as systemic metastases of adrenocortical carcinoma with invasion into the aortic wall and formation of a pseudolumen accompanied by disruption of the vasa vasorum. As far as we know, this is the second case of aortic dissection associated with metastatic carcinoma. The highly aggressive nature of the tumor cells was demonstrated by high mitotic ratio and Ki-67 labeling index. The tumor was also positive for matrix metalloproteinase-12, thus suggesting disruption of the aortic media.