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Acta Neuropathol ; 83(1): 95-8, 1991.
Article in English | MEDLINE | ID: mdl-1792870

ABSTRACT

We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.


Subject(s)
Alzheimer Disease/pathology , Creutzfeldt-Jakob Syndrome/pathology , Aged , Alzheimer Disease/complications , Alzheimer Disease/diagnostic imaging , Amyloid beta-Peptides/metabolism , Atrophy/pathology , Blotting, Western , Brain/diagnostic imaging , Brain/pathology , Brain Chemistry , Creutzfeldt-Jakob Syndrome/complications , Creutzfeldt-Jakob Syndrome/diagnostic imaging , Female , Humans , Immunoenzyme Techniques , Tomography, X-Ray Computed
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