ABSTRACT
We evaluated the efficacy of polymyxin B-immobilized fiber (PMX-F) on organ dysfunction using a rat cecal ligation and perforation (CLP) model. Fifteen-week-old Sprague-Dawley rats (n = 21) were divided into three groups. For a PMX group, n = 7, peritonitis was induced by CLP. After 24 hours from CLP, endotoxin adsorption was performed for 1 hour with a PMX-F column. A sham group, n = 7, external circulation was performed with nonimmobilized fiber column. A control group, n = 7, were sacrificed 25 hours after CLP (no hemoperfusion performed). The changes in interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha and plasminogen activator inhibitor (PAI)-1 were measured. The lungs, liver, and kidneys were stained with hematoxylin and eosin and anti-PAI-1 antibodies. Terminal uridine-triphosphate nick-end labeling assay was performed to evaluate apoptosis. The PMX group showed a tendency to decrease in blood levels of IL-6 and PAI-1 compared with the sham group. Anti-PAI-1 antibody staining was seen in the lungs of the control and sham groups. The PMX group showed significantly decreased apoptotic cells in renal tubule cells compared with sham and control groups. We conclude that PMX-F may have inhibited PAI-1 expression in the lungs and decreased apoptosis of renal tubule cells.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Hemoperfusion/instrumentation , Peritonitis/therapy , Polymyxin B/therapeutic use , Animals , Apoptosis/physiology , Cecum/injuries , Cecum/pathology , Endotoxins/blood , Enzyme-Linked Immunosorbent Assay , Immunohistochemistry , In Situ Nick-End Labeling , Interleukin-10/blood , Interleukin-6/blood , Intestinal Perforation/complications , Ligation , Male , Peritonitis/etiology , Plasminogen Activator Inhibitor 1/metabolism , Rats , Rats, Sprague-Dawley , Tumor Necrosis Factor-alpha/bloodABSTRACT
A 64-year-old man with unresectable sigmoid adenocarcinoma due to peritoneal dissemination (P3) and liver metastasis (H2) treated with TS-1, showed a complete response. TS-1 is an oral anticancer drug that produces biochemical modulation. It is composed of tegafur, gimestat and ostat potassium in a molar ratio of 1:0.4:1 to increase the effect of 5-FU and to decrease toxicity in the digestive canal. Treatment with TS-1 requires no hospitalization and can enhance the quality of life of the patient. TS-1 is expected to be an effective agent for the treatment of colon cancer with liver metastasis and peritoneal dissemination.
Subject(s)
Adenocarcinoma/secondary , Antimetabolites, Antineoplastic/administration & dosage , Liver Neoplasms/secondary , Oxonic Acid/administration & dosage , Peritoneal Neoplasms/secondary , Pyridines/administration & dosage , Sigmoid Neoplasms/drug therapy , Sigmoid Neoplasms/pathology , Tegafur/administration & dosage , Adenocarcinoma/drug therapy , Biomarkers, Tumor/blood , CA-19-9 Antigen/blood , Carcinoembryonic Antigen/blood , Drug Administration Schedule , Drug Combinations , Humans , Liver Neoplasms/drug therapy , Male , Middle Aged , Peritoneal Neoplasms/drug therapy , Remission InductionSubject(s)
Colitis, Ischemic/epidemiology , Age Factors , Arteriosclerosis/complications , Cause of Death , Colitis, Ischemic/classification , Colitis, Ischemic/diagnosis , Diagnosis, Differential , Female , Humans , Hypertension/complications , Japan/epidemiology , Male , Prognosis , Reference Standards , Sex FactorsABSTRACT
Atrue collision carcinoma at the esophagogastric junction is rare. In this article, we report colliding double primary cancers of the esophagus and the stomach in a 68-year-old man and discuss this entity. Pathological analysis after total gastrectomy and partial esophagectomy showed the following findings. Areas of squamous differentiation were found on the esophageal side of the tumor and were adjacent to normal mucosa, and areas of glandular differentiation were found to the gastric side of the tumor and adjacent to normal mucosa. These two tumors collided at the esophago-cardiac junction, but there was no intermingling. In one lymph node, an independent non-intermingled metastatic adenocarcinoma and squamous cell carcinoma were observed. The pathological findings of this case satisfy rigorous criteria for collision carcinoma.
