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1.
Appl Radiat Isot ; 69(12): 1632-4, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21482125

ABSTRACT

At Budker Institute of Nuclear Physics, epithermal neutron source for neutron-capture therapy was built and neutron generation was realized. Source is based on tandem accelerator and uses near-threshold neutron generation from the reaction (7)Li(p,n)(7)Be. The paper describes target optimization through the numerical simulation of proton, neutron and gamma transport by Monte Carlo method (PRIZMA code). It is shown that the near-threshold mode attractive due low activation provides high efficiency of the dose and acceptable therapeutic ratio and advantage depth.

2.
Appl Radiat Isot ; 67(7-8 Suppl): S282-4, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19376729

ABSTRACT

An innovative accelerator-based neutron source for BNCT has just started operation at the Budker Institute of Nuclear Physics, Novosibirsk. One of the main elements of the facility is a lithium target producing neutrons via the threshold (7)Li(p,n)(7)Be reaction at 25 kW proton beam with energies of 1.915 MeV or 2.5 MeV. The design of an optimal target and results of the investigation of radiation blistering of the lithium layer were presented at previous NCT Congresses. During the last two years the neutron target has been manufactured, assembled and placed in the facility. Optimization of the target is carried out with the Monte Carlo simulation code MCNP. In this article, the design of the target is discussed, results of all previous investigations are summarized, results of target testing and neutron generation are described, and results of simulation of neutron spectra are presented.


Subject(s)
Boron Neutron Capture Therapy/instrumentation , Fast Neutrons/therapeutic use , Particle Accelerators , Biophysical Phenomena , Boron Neutron Capture Therapy/statistics & numerical data , Humans , Lithium/radiation effects , Monte Carlo Method , Particle Accelerators/statistics & numerical data , Phantoms, Imaging/statistics & numerical data , Russia
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