ABSTRACT
It was found that the new native antihistamine and antiserotonin drug bicarphen possesses in patients with allergic dermatoses (eczema and neurodermatitis) more active antihistaminic, anti-inflammatory, antipruritic and antiallergic properties than commonly used drugs, particularly in cases with prevalence of exudative and allergic reactions of the immediate type. Normalization of rosette-forming T-lymphocytes and A and G immunoglobulins was essential.
Subject(s)
Dermatitis, Atopic/drug therapy , Histamine H1 Antagonists/therapeutic use , Quinuclidines/therapeutic use , Serotonin Antagonists/therapeutic use , Adolescent , Adult , Antibody Formation/drug effects , Antibody Formation/immunology , Dermatitis, Atopic/immunology , Drug Evaluation , Drug Therapy, Combination , Female , Humans , Immunity, Cellular/drug effects , Immunity, Cellular/immunology , Male , Middle AgedSubject(s)
Dermatitis, Atopic/epidemiology , Dermatitis, Occupational/epidemiology , Adolescent , Adult , Dermatitis, Atopic/chemically induced , Dermatitis, Occupational/chemically induced , Drug-Related Side Effects and Adverse Reactions , Female , Humans , Male , Middle Aged , Mineral Oil/adverse effects , Polymers/adverse effects , RussiaSubject(s)
Eczema/metabolism , Gastric Mucosa/metabolism , Neurodermatitis/metabolism , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Allergological examination of 88 patients with pruritic dermatoses (eczema and neurodermite) and 55 control subjects has demonstrated an important role of food allergy in the pathogenesis of these dermatoses as well as a high percentage of latent food sensitization. Strawberry, citrus and chicken meat appeared to be the most frequently occurring food allergens. Gastrointestinal diseases identified in part of the patients were found to be conducive to the development of food allergy.
