Carbon and metal based magnetic porous materials - Role in drug removal: A Comprehensive review.

Development of effective adsorbents for the removal of contaminants from wastewater is indispensable due to increasing water scarcity and a lack of pure drinking water, which are prevailing as a result of rapid industrialization and population growth. Recently, the development of new adsorbents and their effective use without generating secondary waste is receiving huge consideration. In order to protect the environment from primary and secondary pollution, the development of adsorbents from wastes and their recycling have become conventional practices aimed at waste management. As a result, significant progress has been made in the synthesis of new porous carbon and metal-organic frameworks as adsorbents, with the objective of using them for the removal of pollutants. While many different kinds of pollutants are produced in the environment, drug pollutants are the most vicious because of their tendency to undergo significant structural changes, producing metabolites and residues with entirely different properties compared to their parent compounds. Chemical reactions involving oxidation, hydrolysis, and photolysis transform drugs. The resulting compounds can have detrimental effects on living beings that are present in soil and water. This review stresses the development of adsorbents with adjustable porosities for the broad removal of primary drug pollutants and their metabolites, which are formed as a result of drug transformations in environmental matrices. This keeps adsorbents from building up in the environment and prevents them from becoming significant pollutants in the future. Additionally, it stops secondary pollution caused by the deterioration of the used adsorbents. Focus on the development of effective adsorbents with flexible porosities allows for the complete removal of coexisting contaminants and makes a substantial contribution to wastewater management. In order to concentrate more on the development of flexible pore adsorbents, it is crucial to comprehend the milestones reached in the research and applications of porous magnetic adsorbents based on metal and carbon, which are discussed here.

Exploring the impact of circular RNA on ALS progression: A systematic review.

Amyotrophic lateral sclerosis is a neurodegenerative disease that damages motor neurons and causes gradual muscular weakening and paralysis. Although studies have linked a number of genetic and environmental factors to ALS, the specific causes and mechanisms of the disease are still unclear. The pivotal role of circular RNA in the pathogenesis of ALS is a newly emerging area of research. The term "circular RNA" describes a particular class of RNA molecule that, in contrast to most RNA molecules, has a closed-loop structure. According to recent research, circular RNA might be essential for the development and progression of ALS. It has been discovered that these circular RNAs support important cellular functions related to ALS, including protein turnover, mitochondrial function, RNA processing, and cellular transport. Gaining knowledge about the precise roles and processes of circular RNA in the development of ALS could assist in understanding the pathophysiology of the disease and possibly pave the way for the development of targeted therapies. However, the understanding of circular RNA in ALS is still limited, and more research is needed to fully elucidate its role. In order to gain a comprehensive understanding of the role of circRNAs in ALS, it is imperative to delve into the various mechanisms through which circRNAs may contribute to the development and progression of the disease. Examining the current status of circRNA research in ALS and offering insights into their potential as therapeutic targets and diagnostic markers are the primary objectives of this review.

Computational identification and molecular dynamics simulation of potential circularRNA derived peptide from gene expression profile of Rheumatoid arthritis, Alzheimer's disease, and Atrial fibrillation.

The two most serious global health challenges confronting human society today are autoimmune disorders (AIDs) and neurological diseases (NDs), both of which shorten people's lives and worsen the situation. Despite their extensive impact, statistics show that AIDs is associated with a higher risk of ND. Circular RNAs (circRNAs) are critical in several illnesses and disorders, especially AID and ND. Therefore, the present study focused on understanding the underlying causes of the pathophysiology of diseases such as AID and ND through in silico-based research. In order to determine how circRNAs are related to various disease pathways, this study examined the gene expression data sets for Rheumatoid arthritis (RA), Alzheimer's disease (AD), and atrial fibrillation (AF). Our study identified and analyzed two circRNAs, their respective host genes (DHTKD1 and RAN) and their related miRNAs, which could serve as potential markers for treating disorders like myotonic dystrophy type 1, spinocerebellar ataxia and fragile X syndrome. Further, the circRNA-derived peptide was identified and analysed with the molecular dynamics simulation (MDS) followed by a principal component (PC) based free energy landscape (FEL) profile. The computational results obtained here provide a basis for the development of therapeutics against AD, RA and AF. Moreover, further functional studies are needed to validate their role in disease aetiology and to provide a detailed understanding of their association with AID and ND.Communicated by Ramaswamy H. Sarma.

HighlightsSignificant circular RNAs associated with autoimmune disorders and neurological diseases are identifiedIdentified circular RNAs and their host genes (DHTKD1 and RAN) impacted multiple disease pathwaysThe stability of circularRNA-derived peptide was checked with MD simulation followed by PCA-based FEL analysisThe potential of circular RNAs as biomarkers or therapeutic targets for human diseases was highlighted.

Differential gene expression analysis combined with molecular dynamics simulation study to elucidate the novel potential biomarker involved in pulmonary TB.

Tuberculosis (TB) is a lethal multisystem disease that attacks the lungs' first line of defense. A substantial threat to public health and a primary cause of death is pulmonary TB. This study aimed to identify and investigate the probable differentially expressed genes (DEGs) primarily involved in Pulmonary TB. Accordingly, three independent gene expression data sets, numbered GSE139825, GSE139871, and GSE54992, were utilized for this purpose. The identified DEGs were used for bioinformatics-based analysis, including physical gene interaction, Gene Ontology (GO), network analysis and pathway studies using the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG). The computational analysis predicted that TNFAIP6 is the significant DEG in the gene expression profiling of TB datasets. According to gene ontology analysis, TNFAIP6 is also essential in injury and inflammation. Further, TNFA1P6 is strongly linked to arsenic poisoning, evident from the results of NetworkAnalyst, a comprehensive and interactive platform for gene expression profiling via network visual analytics. As a result, the TNFAIP6 gene was ultimately chosen as a candidate DEG and subsequently employed for in silico structural characterization studies. The tertiary structure of TNFAIP6 was modelled using the ROBETTA server, followed by validation with SAVES and ProSA webserver. Additionally, structural dynamic studies, including molecular dynamics simulation (MDS) and essential dynamics analysis, including principal component (PC) based free energy landscape (FEL) analysis, was used for checking the stability of TNFAIP6 models. The dynamics result established the structural rigidity of modelled TNFAIP6 through RMSD, RMSF and RoG results. The FEL analysis revealed the restricted conformational flexibility of TNFAIP6 by displaying a single minimum energy basin in the contour plot. The comprehensive computational analysis established that TNFAIP6 could serve as a viable biomarker to assess the severity of pulmonary TB.

Studies on temperature impact (sudden and gradual) of the white-leg shrimp Litopenaeus vannamei.

In the present study, the effect of temperature shock (sudden and gradual) by increasing water temperature from 28 °C to 40 °C on survival, behavioral responses and immunological changes in Litopenaeus vannamei (L. vannamei) was studied. In sudden temperature shock, experimental groups were maintained at different temperature ranges such as 28 °C- 31 °C; 28 °C-34 °C; 28 °C-37 °C and 28 °C-40 °C along with 28 °C as control. For gradual temperature shock experiments, the initial water temperature was maintained at 28 °C for 24 h in control and then increased to 1 °C for every 24 h until reaching 40 °C. On reaching the final temperature of 40 °C, it was kept stable for 120 h. Results indicated that the increasing water temperature (sudden shock) affected survival, behavioral responses and immunological parameter. No shrimp survived at 40 °C treatment (sudden), whereas in the gradual temperature shock experiment 20% of animals survived at 40 °C. The increasing water temperature had no effects on behavioral responses up to 37 °C (gradual), but at 40 °C the observation of muscle cramps, low swimming rate, no feeding, muscle and hepatopancreas color turned whitish. Overall, the results suggest that L. vannamei can tolerate water temperature up to 34 °C under sudden shock and 37 °C under gradual shock conditions. This study reveals that shrimp L. vannamei can self-regulate to a certain extent of temperature variation in the environment.

Bioremediation by oil degrading marine bacteria: An overview of supplements and pathways in key processes.

Oil spillage is one of the most common pollutants which brings greater economic loss and damage to the environment. The intensity and amount of the damage may vary depending on factors such as the type of oil, the location of the spill, and the climatic parameters in the area. As for any pollution management, the guidelines are Reduce, Re-use, Recover and Disposal. Amongst the other remediation processes, Bioremediation is amongst the most significant environmentally friendly and cost-effective approaches for marine biological restoration because it allows complex petroleum hydrocarbons in spilt oil to decompose completely into harmless compounds. Mainly, the necessity and essence of bioremediation were talked about. This review discussed the bacteria identified which are capable of degrading various oil related pollutants and their components. Also, it covered the various media components used for screening and growing the oil degrading bacteria and the pathways that are associated with oil degradation. This article also reviewed the recent research carried out related to the oil degrading bacteria.

Pyrolysis temperature influences the characteristics of rice straw and husk biochar and sorption/desorption behaviour of their biourea composite.

Biochar obtained by biomass pyrolysis has several energies, environmental, and agricultural applications. In the present study, influence of pyrolysis temperatures (300 °C, 450 °C and 600 °C) on characteristics of rice residue biochar and sorption/desorption pattern of biourea was investigated. Biochar yield was reduced with the increasing temperature accompanied with increasing carbon content, pH, and electrical conductivity. Elemental O:C and H:C ratios of biochar decreases with temperature. Half-life was predicted between 500 and 750 years varying positively with pyrolysis temperature. Urea sorption/ desorption studies revealed ˃90% sorption in both rice straw and husk biochar with highest urea adsorption at 450 °C, while desorption was more sustained in rice straw biourea. Microporosity, cation exchange capacity and functional groups primarily carboxyl and keto group, played key role in sorption/desorption pattern of biourea with slow release kinetics. Rice residue based biourea composites have potential to raise the crop yields and nitrogen use efficiency.

Synthesis and characterization of silver nanoparticles using crystal compound of sodium para-hydroxybenzoate tetrahydrate isolated from Vitex negundo. L leaves and its apoptotic effect on human colon cancer cell lines.

Metallic nanoparticles are major concern, particularly silver nanoparticles (AgNPs) are used in various applications. In the present investigation, we report a novel strategy with biological approach for synthesis of AgNPs using sodium para-hydroxybenzoate tetrahydrate (SPHT) isolated from Vitex negundo leaves. The synthesized SPHT-AgNPs were characterized by UV-vis spectroscopy, high resolution transmission electron microscopy (HRTEM) with selected area electron diffraction (SAED) pattern, field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDX), zeta potential and Fourier transform infrared spectroscopy (FT-IR) analysis. The various pH and temperature were evaluated to find their stability effects on SPHT-AgNPs synthesis peak at 430 nm. The size of SPHT-AgNPs were ranging from 26 to 39 nm and were spherical in shape. The hydroxyl and carboxylic functional groups from bio-reducing mediators of SPHT have a stronger ability towards synthesis of AgNPs, which was confirmed using FT-IR spectrum. In addition, anticancer activity were determined by MTT assay, Annexin V-FITC/PI and cell cycle analysis.