Effect of repeatedly applied cold water immersion on subclinical atherosclerosis, inflammation, fat accumulation and lipid profile parameters of volunteers.

Significant acute cardiovascular, metabolic, and endocrine changes have been traced to short-lasting cold water immersion (CWI); however, the long-term impact of recurrent CWI on atherogenesis, lipid parameters, and fat distribution has not yet been studied. The goal of this study was to investigate the alleged protective effect. A total of 35 healthy volunteers were monitored for a period of 5 months during which the CWI was performed under standardized conditions (three times per week for 7-10 min, without neoprene equipment). Volunteers with measured weight or muscle mass increases of more than 5% were ineligible. An analogous control group (N = 30) was included. At the onset and completion of the study, blood samples were obtained, and clinical assessments took place. PCSK9 and hsCRP levels were measured together with other lipid-related and non-lipid-related indicators. Carotid intima-media thickness test (cIMT) and echo-tracking for the identification of arterial stiffness (PWV, AI, and ß) were used to identify early vascular alterations. Hepatorenal index (HRI) calculations served to quantify liver steatosis, while changes in subcutaneous and visceral fat thickness were used to quantify fat distribution. The given protocol was successfully completed by 28 volunteers. Long-term repeated CWI resulted in a significant decline in cIMT (p = 0.0001), AI (p = 0.0002), Beta (p = 0.0001), and PWV (p = 0.0001). PCSK9 (p = 0.01) and hsCRP (p = 0.01) showed a significant decrease when compared to initial values. In comparison to the starting values, liver fat accumulation decreased by 11% on average (HRI p = 0.001). LDL, TC, TG, and VLDL levels all significantly decreased as well. We suggest that repeated CWI may have beneficial impact on lipid, non-lipid, and lipid-related indices, as well as atherogenesis and liver fat storage.

The Impact of Vibration Therapy Interventions on Skin Condition and Skin Temperature Changes in Young Women with Lipodystrophy: A Pilot Study.

BACKGROUND: Cellulite affects 85-98% of women aged over 20 years. In a given context, mechanical vibrations have not been applied in the therapy of gynoid lipodystrophy (GL) until now. The aim of this pilot study was to assess the condition and temperature of skin affected by cellulite after vibration therapy interventions in young women with GL. METHODS: 10 healthy women (21.5 ± 1.5 years old) with stage 1 or 2 Nürnberger-Müller scale of severity of GL participated in the study. The subjects underwent 20 vibration interventions with the use of a Rehabilitation Massage Device Vitberg+. Vibration therapy was applied 5 times a week for 60 minutes during 4-week period. Before and after first and last interventions, grade of lipodystrophy was assessed and thermographic images were taken. RESULTS: Visual and palpation analysis performed before and after a series of treatments proved a total cellulite remission after the intervention among 40% of subjects (from stage 1 to stage 0). Among the remaining 60% with stage 2 of cellulite, an improvement in the skin condition was observed, and cellulite grade was determined as stage 1. The mean skin temperature in the lateral part of thigh as well as on the posterior surface of thigh and buttocks increased significantly (p<0.00001) after both the first (respectively: 4.0°C ± 0.9°C, 3.9°C ± 0.8°C) and the last vibration therapy interventions (respectively: 3.1°C ± 1.1°C, 2.8°C ± 1.1°C). After the series of interventions, a statistical significant (p=0.00705) increase in the mean skin temperature in the lateral thigh was observed-before the first treatment: 27.9°C ± 0.7°C; before twentieth treatment: 29.0°C ± 1.2°C. CONCLUSION: The series of vibration interventions contributed to the reduction of GL among the participants. The thermographic imaging analysis proved an impact of both single and serial vibration interventions.