Morphological evaluation of gonial and antegonial regions in bruxers on panoramic radiographic images.

BACKGROUND: This is the first study to report both cortical and trabecular bone evaluation of mandibles in bruxers, within the knowledge of the authors. The purpose of this study was to evaluate the effects of bruxism on both the cortical and the trabecular bone in antegonial and gonial regions of the mandible, which is the attachment of the masticatory muscles, by using panoramic radiographic images. METHODS: In this study, the data of 65 bruxer (31 female, 34 male) and 71 non-bruxer (37 female, 34 male) young adult patients (20-30 years) were evaluated. Antegonial Notch Depth (AND), Antegonial-Index (AI), Gonial-Index, Fractal Dimension (FD) and Bone Peaks (BP) were evaluated on panoramic radiographic images. The effects of the bruxism, gender and side factors were investigated according to these findings. The statistical significance level was set atP ≤ 0.05. RESULTS: The mean AND of bruxers (2.03 ± 0.91) was significantly higher than non-bruxers (1.57 ± 0.71; P < 0.001). The mean AND of males was significantly higher than females on both sides (P < 0.05). The mean AI of bruxers (2.95 ± 0.50) was significantly higher than non-bruxers (2.77 ± 0.43; P = 0.019). The mean FD on each side was significantly lower in bruxers than in non-bruxers (P < 0.05). The mean FD of males (1.39 ± 0.06) was significantly higher than females (1.37 ± 0.06; P = 0.049). BP were observed in 72.5% of bruxers and 27.5% of non-bruxers. The probability of existing BP, in bruxers was approximately 3.4 times higher than in non-bruxers (P = 0.003), in males was approximately 5.5 times higher than in females (P < 0.001). CONCLUSION: According to the findings of this study, the morphological differences seen in cortical and trabecular bone in the antegonial and gonial regions of the mandible in bruxers can be emphasized as deeper AND, higher AI, increased of existing BPs, and lower FD, respectively. The appearance of these morphological changes on radiographs may be useful for indication and follow-up of bruxism. Gender is an effective factor on AND, existing BP and FD.

Does isotretinoin affect spermatogenesis in the long term? A rat model.

OBJECTIVES: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. MATERIALS AND METHODS: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4th week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index, sperm number and motility recorded Results: Sperm count, motility, vitality, diameter of seminiferous tubule and germinal epithelium thickness were decreased and apoptotic index increased in the groups received isotretinoin. There was no significant difference between the groups in terms of testosterone levels. CONCLUSIONS: We consider that further comprehensive studies, including human clinical trials, should be conducted to examine the negative effects of isotretinoin on spermatogenesis in the long term especially when there is a need using isotretinoin in men for various reasons and to eliminate the contradictions in the literature in this regard.

Effect of ultraviolet protective agents on maxillofacial silicone elastomer, part 1: Color stability after artificial aging.

STATEMENT OF PROBLEM: Silicone elastomers have been widely used for rehabilitation of facial defects for more than 50 years. However, color change is the most common problem limiting the service life of facial prostheses. Whether the addition of ultraviolet protectives may enhance color stability of these materials is unclear. PURPOSE: The purpose of this in vitro study was to investigate the effect of ultraviolet protectives on the color stability of maxillofacial silicones after artificial aging. MATERIAL AND METHODS: Six color groups (unpigmented, white, yellow, red, blue, and mixed) of addition-type maxillofacial silicone were prepared. Four ultraviolet protectives benzophenone-3, ethylhexyl methoxycinnamate, titanium dioxide, and ethylhexyl salicylate at 0.5% and 1% concentrations by weight were incorporated into the silicone before polymerization. The specimens were artificially aged in an accelerated weathering chamber for 300 and 600 hours and in a thermocycling device. The color change values (E) of the maxillofacial silicones were evaluated. Data were statistically analyzed by using 4-way ANOVA. The differences were compared by the Tukey honestly significant difference test (α=.05). RESULTS: Benzophenone-3 and ethylhexyl methoxycinnamate protectives did not reduce the ΔE values, and the 1% titanium dioxide groups exhibited lower ΔE values than the 0.5% titanium dioxide groups. Ethylhexyl salicylate protective generally reduced the ΔE values significantly in all color and aging groups when compared with the control groups (P<.05). In all control and ultraviolet protective groups, the highest ΔE values were seen with the red color in 300 and 600 hours of aging. Generally, no significant difference (P>.05) was seen in the ΔE values, which were clinically acceptable among the thermocycled color groups. After 600 hours of accelerated aging, the ΔE values were found to be higher than the values of 300-hour aging. CONCLUSIONS: Ethylhexyl salicylate protective incorporated into maxillofacial silicones may improve color stability.

Effect of ultraviolet protective agents on maxillofacial silicone elastomer, part 2: Mechanical properties after artificial aging.

STATEMENT OF PROBLEM: The addition of ultraviolet (UV) protectives may affect the materials' mechanical properties, which can limit the service life of facial prostheses. PURPOSE: The purpose of this in vitro study was to investigate the effect of UV protectives on the mechanical properties of maxillofacial silicones after artificial aging. MATERIAL AND METHODS: Six color groups (unpigmented, white, yellow, red, blue, and mixed) of addition-type maxillofacial silicone were prepared. Four UV protectives, benzophenone-3 (UV-BP), ethylhexyl methoxycinnamate (UV-EM), titanium dioxide (UV-TD), and ethylhexyl salicylate (UV-ES), at 0.5% and 1% concentrations by weight were incorporated into the silicone before polymerization. The specimens were subjected to accelerated aging in a weathering chamber for 300 and 600 hours and to thermocycling. The tensile strength and percentage elongation, tear strength, and hardness of maxillofacial silicones were evaluated. Data were analyzed by using 4-way ANOVA. The differences were compared by the Tukey honestly significant difference test (α=.05). RESULTS: Tensile strength decreased after 300 and 600 hours of UV aging in 0.5% and 1% UV-BP protective-added groups and increased in thermocycled groups (P<.05). Aging conditions generally showed no effect on the tensile strength of UV-EM, UV-TD, and UV-ES added groups (P>.05). Aging generated a decrease in percentage elongation values compared with nonaged specimens of groups (P<.05). The addition of UV protectives generally did not significantly affect the tear strength of specimens compared with control in the aged groups (P>.05). The hardness of UV protective-added groups increased when compared with that of nonaged groups after 300 and 600 hours of UV aging (P<.05). Also, thermally aged groups showed increased hardness than nonaged groups (P<.05). CONCLUSIONS: The protective UV-BP addition caused decreased tensile strength, percentage elongation, and tear strength in both concentrations. The UV-EM and UV-ES provided increases in tensile strength and percentage elongation of the silicone in the 0.5% concentration. The addition of UV-BP, UV-EM, and UV-ES did not make significant differences; however, UV-TD significantly decreased the hardness values of the silicone.

Training female adolescent students with intellectual disabilities about genital hygiene skills using peer training.

Purpose: The study aimed to evaluate the effects of peer training of female adolescent students diagnosed with intellectual disabilities and started menses, about genital hygiene and menstrual care skills on a baby doll. Methods: This study was planned as a non-control group research design including pre-test, post-test and follow-up stages. It was conducted in special educational institutions. The population consisted of 68 female students between 10-18 years old. Calculation of sample size was not performed, and 65 students were included in the study. The data were collected using Socio-Demographic Form, Genital Cleansing Skill Form (GCSF), Pad Replacement Skill Analysis Form (PRSAF), and Teacher/Parent Opinion and Feedback Form. The statistical analysis of the study data was performed using Mc-Nemar test, Mann-Whitney U test, Kruskal-Wallis test and Friedman test followed by Dunn-Bonferroni post-hoc test. Results: In all follow-up periods, GCSF and PRSAF scores compared by Mann-Whitney U and Kruskal-Wallis tests did not change based upon demographic characteristics (p > 0.05). Friedman test showed that GCSF and PRSAF scores showed significant differences between the follow-up periods (p < 0.001). According to Dunn-Bonferroni post-hoc test, there was no statistically significant difference between 2nd and 3rd follow-up scores with respect to both GCSF and PRSAF (p > 0.05). However, 2nd and 3rd follow-up scores were found to be significantly higher than 1st follow-up score (p < 0.05). Conclusion: The study demonstrated that menstrual care skills of female adolescent students with intellectual disabilities improved after training and peer training was found to be effective. Peer training can be useful when used as continuing training to help individuals achieving a higher criterion of mastery.

Effect of Antibiotic Exposure on Upper Respiratory Tract Bacterial Flora.

BACKGROUND The human microbiota modulates the immune system and forms the surface flora. Antibiotic administration causes dysbiosis in the intestinal flora. It is not clear if antibiotic administration in the community effects the upper airway flora in the mid-term or long-term. This study aims to define long-term influence of antibiotics on upper airway flora. MATERIAL AND METHODS In this prospective study, aerobic microbiological analysis of nasal and nasopharyngeal surfaces was performed. Antibiotic administration history of the last 6 months was retrieved using the social insurance database. Culture results of antibiotic-treated and antibiotic-naïve subjects were compared by Pearson's chi-square test or Fisher's exact test. RESULTS A total of 210 subjects were included in the study. Normal flora were documented in 86 nasal swabs and 99 nasopharyngeal swabs. Most of the remaining cases demonstrated gram-positive bacterial overgrowth. There were 113 subjects who did not receive any antibiotic, and 93% of the remaining 97 patients received broad-spectrum antibiotics. Statistical analysis showed that nasal and nasopharyngeal flora did not change upon antibiotic administration, but antibiotic administration during the last month caused increased methicillin resistance development of coagulase-negative Staphylococcus and Staphylococcus aureus microorganisms. CONCLUSIONS Antibiotic exposure did not lead to perturbations in general composition of upper airway flora within 6 months, although the incidence of methicillin resistance in coagulase-positive and -negative Staphylococci demonstrated significant increases when patients received antibiotic during the last month. This should be considered in case of broad-spectrum antibiotic administration, since methicillin resistance increases the morbidity and mortality of nosocomial Staphylococcus infections.

The relationship between problematic Internet use in adolescents and emotion regulation difficulty and family Internet attitude.

The study aims to determine the relationship between problematic Internet use in adolescents and emotion regulation difficulty and family Internet attitude. The study used a descriptive and correlational design. The sample of the study consisted of 5916 students. The data were collected using the "Problematic Internet Use Scale," "Difficulties in Emotion Regulation Scale," "Internet Parental Style Scale." The total score on the Problematic Internet Use Scale was 55.41 ± 19.60 while the total score on the Difficulties in Emotion Regulation Scale was 97.51 ± 17.84. Considering the Internet parental styles, it was found that 42.89% of the parents had a negligent attitude. According to the results of the logistic regression analysis performed, grade level was found to affect problematic Internet use. A highly significant correlation was found between problematic Internet use and emotional regulation difficulties and family control of family Internet attitude (p < 0.01). This study determined that adolescents' grade level and excessive Internet use of the father were effective in the problematic Internet use of the adolescents. Adolescents' difficulties in emotion regulation and the type of families' attitudes towards Internet use were associated with problematic Internet use. In accordance with these results, it can be recommended to form programs to decrease problematic Internet use.

Determining the factors affecting the gestational length in sheep.

This research aimed to determine the effects of body weight, the body condition score (BCS), body measurements, birth type (single offspring or twin birth), birth weight and sex on the gestational length in sheep ( n = 111 ). Karayaka sheep raised on a private farm were used in the study. Progeny yield characteristics in sheep were also determined ( n = 139 ). Estrus was monitored daily using teaser rams from August to September 2016. According to our findings, the pregnancy rate, infertility rate, fecundity, and twin and single birth rates were 93.52 %, 6.48 %, 93.52 %, 14.62 % and 85.38 % respectively. The effect of age on the BCS in sheep at mating was found to be significant ( P < 0.05 ): BCS decreased as age increased. It was determined that there was a positive association between the BCS and live weight during the mating period ( P < 0.001 ). The chest circumference, front shin circumference and body length were found to be higher in sheep with a BCS ≥ 4.5 at mating time ( P < 0.01 ). The middle rump width was significantly affected by the BCS ( P < 0.001 ). In this study, the lowest and highest gestational lengths were found to be 148.90 and 151.41 d respectively. The gestational length in sheep was not found to be affected by age, the BCS, body measurements, sex or birth type ( P > 0.05 ); however, it was observed that the gestational lengths for male offspring and single offspring (non-multiple births) were longer. In addition, it was detected that the gestational length was different in sheep with a BCS ≥ 4.5 . The time spent in the womb is important with respect to obtaining a healthy lamb. For profitable production, a BCS of between 2.5 and 4 is recommended in sheep. It is thought that the use of body condition scoring, which is easy information for the breeder to utilize, will have a positive effect on determining the bodily reserves of sheep and the reproductive efficiency as well as on obtaining a healthy lamb. More studies on the gestational length in sheep are required.

Is erectile dysfunction an early clinical symptom of chronic kidney disease?

OBJECTIVES: Erectile dysfunction (ED) is the persistent inability to attain and/or maintain erection sufficient for satisfactory sexual performance. Chronic kidney disease (CKD) is a problem with increasing incidence every day which disrupts quality of life significantly. We aimed to research whether ED is a warning symptom for the early stages of CKD or not. MATERIALS AND METHODS: The records of 639 patients attending Ordu University due to ED were retrospectively investigated. According to International Index of Erectile Function (IIEF) scores and degree of ED, patients were compared in terms of GFR values. RESULTS: In 92.8% of patients, serum creatinine values were within normal limits (<1 mg/dL), while 30.5% of patients were observed to have GFR below 80. While stage 2 CKD was identified in 1% of the control group, this rate was calculated as 8% in the group with severe ED. In stage 1 and stage 2 CKD, IIEF scores were identified to be low by clear degree. CONCLUSIONS: Results confirm that it was identified that the incidence of stage 1 and stage 2 CKD was higher among patients attending with ED compared to the control group. Just as ED may be an early clinical marker of coronary artery disease, it may be early warning symptom for CKD.

Serum C-reactive protein/albumin ratio and restless legs syndrome.

OBJECTIVES: Our study aimed to assess the variation in serum C-reactive protein/albumin ratio (CAR), a biomarker of peripheral inflammation and oxidative stress, in patients with restless legs syndrome (RLS). METHODS: The study included a total of 380 individuals including 197 with RLS diagnosis. RLS diagnosis was determined according to the "International Restless Legs Syndrome Study Group" questionnaire. Disease severity was assessed according to the "International Restless Legs Syndrome Study Group Severity Scale''. RESULTS: The mean age of patients with restless legs syndrome was 52.5 ± 12.7 years, while the mean age in the control group was 50.8 ± 11.2, with no statistically significant difference found (p = 0.156). The hemoglobin, iron and ferritin levels in the patient group were lower than in the control group (p < 0.001; p < 0.01; p < 0.001), with total iron binding capacity levels higher than the control group (p < 0.001). The mean ferritin in the RLS group (49.8 ± 51.2) was lower than the control group (76.9 ± 44.7). In patients, the c-reactive protein, albumin and c-reactive protein/albumin ratio were found to be 0.21 ± 0.18, 4.43 ± 0.31 and 0.07 ± 0.05, respectively. When compared with the control group, the patient group had high c-reactive protein (CRP), CAR and low albumin levels (p < 0.001). Among patients with "very severe" disease severity, ferritin levels were found to be lower than those with "moderate" disease severity. Additionally, patients with "very severe" disease had albumin levels which were significantly low compared to those with "mild" disease severity (p < 0.05). CONCLUSION: Our study supports the hypothesis that serum albumin level, ferritin, CRP, and CAR may be associated with restless legs syndrome.

In vitro evaluation of color and translucency reproduction of maxillofacial prostheses using a computerized system.

PURPOSE: Accurate color matching of maxillofacial prostheses to skin is important for esthetics. A computerized color matching system specific to human skin has recently been developed. The purpose of this study was to evaluate the accuracy in color and translucency matching of the computerized color matching system across different skin colors. MATERIALS AND METHODS: The silicone was colored to simulate 28 different skin colors (n=5) to serve as "target skin colors". Using a spectrocolorometer (e-skin), color codes were determined for "replicate skin color" fabrication. CIELAB Delta-E between target skin color-replicate skin color pairs and translucency parameter were calculated. CIELAB Delta-E values were compared with one-way ANOVA and Tukey multiple-comparison. The agreement between L*, a*, b* and translucency parameter of target skin colors and replicate skin color were calculated by a two-way mixed average measures intraclass correlation coefficient. Translucency parameter of target skin color-replicate skin color pairs were compared with Paired t-test (α=.05). RESULTS: The mean CIELAB Delta-E value was 3.83 and significant differences were found among colors. The intraclass correlation coefficient showed excellent reliability for L*, a*, b* and good reliability for translucency parameter (P<.001). The mean translucency parameter of replicate skin colors was significantly higher than that of translucency parameter. CONCLUSION: The computerized color matching system specific to human skin was found to be reliable in terms of color and translucency between target skin colors and replicate skin color.