1.
J Org Chem
; 76(23): 9841-4, 2011 Dec 02.
Article
in English
| MEDLINE
| ID: mdl-21988595
ABSTRACT
Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (<0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.