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Bioorg Med Chem Lett ; 21(10): 2823-5, 2011 May 15.
Article in English | MEDLINE | ID: mdl-21493063

ABSTRACT

Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.


Subject(s)
Amides/chemical synthesis , Hydroxamic Acids/chemical synthesis , Matrix Metalloproteinase Inhibitors , Protease Inhibitors/chemical synthesis , Amides/chemistry , Humans , Hydroxamic Acids/chemistry , Inhibitory Concentration 50 , Molecular Structure , Protease Inhibitors/chemistry , Structure-Activity Relationship , Substrate Specificity
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