ABSTRACT
OBJECTIVE: Nonsurgical treatment of Dupuytren's disease using collagenase Clostridium histolyticum (CCH). INDICATIONS: Metacarpophalangeal (MP) joint (20-100°) and proximal interphalangeal (PIP) joint (20-80°) contractures. CONTRAINDICATIONS: Pregnancy, previous hypersensitivity to collagenase or excipients, anticoagulant use within 7 days prior to treatment. INJECTION TECHNIQUE: CCH injected directly into the Dupuytren's cord weakening the contracted cord. After injection, the patient returns the following day to allow CCH to lyse the collagen within the cord. An extension force is then applied to the involved finger to disrupt the weakened cord. POSTMANIPULATION MANAGEMENT: Use of extension splint at night, movement instructions during the day. RESULTS: A total of 120 patients (107 men; 13 women; mean age 62 years, range 30-84 years) were treated. In 49% the little finger, in 44% the ring finger, in 4% the middle finger, and in 3% the index finger was treated. Full release was achieved in 71%, partial release in 26%, and no change in 3% of patients. The median pretreatment contracture for the MP joint was 37° (range 25-100°) and PIP joint 51° (range 30-97°). At 12 months, the mean contracture for the MP joint was 9° (range 0-25°) and for the PIP joint 21° (range 10-36°). Adverse events observed in 96% of patients for 3 months . No tendon ruptures, anaphylactic reactions, or nerve or ligament injuries observed.
Subject(s)
Dupuytren Contracture/therapy , Microbial Collagenase/therapeutic use , Musculoskeletal Manipulations/methods , Adult , Aged , Aged, 80 and over , Combined Modality Therapy/methods , Dupuytren Contracture/diagnosis , Female , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
OBJECTIVE: Reduction and stabilization of osteoporotic vertebral body fractures using posterior short-segment instrumentation. Cement augmentation of the pedicle screws in order to improve the screw's holding power in osteoporotic bone and to reduce postoperative loss of reduction. Quick and painless postoperative mobilization without further bracing. INDICATIONS: Burst fractures (type A3 according to Magerl). Posttraumatic kyphosis following osteoporotic vertebral body fractures. Revision surgery after screw loosening. Type B and C fractures according to Magerl. CONTRAINDICATIONS: Osteoporotic fractures which are suitable for nonoperative treatment or percutaneous cement augmentation techniques (vertebroplasty, kyphoplasty). Vertebral body fractures in patients with good bone quality. SURGICAL TECHNIQUE: Insertion of pedicle screws in a typical manner. If perforated screws are used, cement application under fluoroscopic control via the central perforation of the screws. If pedicle screws without perforation are used, application of the cement using a Kyphoplasty technique and insertion of the screws. After hardening of the cement, completion of the instrumentation. POSTOPERATIVE MANAGEMENT: Mobilization starting on the first day after surgery. Avoidance of heavy lifting and manual labor for 3 months. Implant removal only if it is necessary due to complications. RESULTS: Between July 2008 and December 2009, 10 patients with osteoporotic vertebral body fractures of the thoracic and lumbar spine were treated with cement-augmented posterior instrumentation. The mean age was 65.8 years (range 3594 years). There were six type A (2 A1 and 4 A3 lesions) and four type B lesions (1 B1, 1 B2, and 2 B3 lesions) according to Magerl. Indications for cement augmentation of the pedicle screws were the patients' age (4 patients), osteoporosis with t scores < − 2.5 (2 patients), poor intraoperative screw hold (2 patients), and revision surgery after loosening of pedicle screws (2 patients). Cement leakage was observed in 5 patients with no further clinical relevance. Loosening of cement augmented pedicle screws occurred in 1 patient with a consecutive loss of reduction of 10°. There was no need to remove any of the cement-augmented screws in the first 24 months.
