[The hematological and biochemical changes in workers exposed to benzol]. / Khematologichni i biokhimichni promeni pri rabotnitsi, eksponirani na benzol.

The study embraces 122 workers from two productions, where the leading chemical noxious in the working environment is benzol. The workers are distributed in groups according to the calculated index of exposure in view of looking for dependence dose-effect. Routine indices of peripheral blood are examined as well as the activity of myeloperoxidase and alkaline phosphatase in leucocytes. An organ-orientated screening, most frequently used for assessing the state of the liver was used. In a large group of workers (mainly from those with high index of exposure) are established early changes in leucocytes: neutropenia, toxic granules, strongly inhibited alkaline phosphatase in the granulocytes and tendency to leukopenia. It was confirmed, that the strongly inhibited alkaline phosphatase, find, which is established also in other workers with benzol exposure, is an early sign for myelotoxic effect of benzol. The biochemical study of workers gives no data for deviations in the functional status of the liver. Single changes in the indices are found characterizing lipid metabolism in workers from Ist risk group of both productions.

[Working conditions and morbidity with temporary loss of work capacity among metallurgists from Mill 300 of the Predmet firm--in Debelt]. / Usloviia na trud i zaboliaemost s vremenna netrudosposobnost sred metalurzite ot Stan 300 na firma "Promet"--Debelt.

Occupational hygienic and medico-statistical study is carried out in shop LOOM-300 for rolling of steel. The rate of exposure to chemical and dust factor of the workers is determined by means of index of exposure after the formula [formula: see text] The personal analysis of morbidity with temporary disability shows an increase of the basic indices "frequency" and "gravity" during the three year period. The per cent of the sick is higher in men, in the workers with higher index of exposure and in the younger age groups (up to 40 years old) with short labour of service, which certifies, for insufficient adaptation to the new working conditions. A conclusion is made, that the progressive increase of the indices of morbidity are serious warning for future high rate of morbidity, if labour hygienic and medico-preventive measures are not taken.

[The relationship of exposure to chemically harmful compounds and disorders of the health status in workers in ethylene production]. / Zavisimost mezhdu ekspozitsiiata na khimichnite vredni suedineniia i narusheniiata v zdravoslovnoto sustoianie na rabotnitsite ot proizvodstvo "Etilen".

On the basis of job characteristics of workers from the production "ethylene", chronometric studies and measurement of concentration from chemical compounds are developed professional diagrams and risk diagrams, which give a possibility for more precise account of the exposure to chemical noxious compounds (by figures). According to the values of the estimated total index of exposure 156 workers are distributed in 5 groups. Besides, 48 workers with prolonged length of service in the production and 37 persons control group are examined. The toxicological, haematological and biochemical indices are studied and the neuro-vegetative status traced. Mainly in the groups with high chemical exposure (first and second risk groups) and with prolonged length of service are established high per cent of workers with deviation in the examined indices, which give grounds to assert for the presence of dose-response relationship.