[Fucosylation of serum proteins in stomach cancer]. / Fukozilirovanie belkov syvorotki krovi pri rake zheludka.

Content of fucose and of fucosylated protein fractions was studied in blood serum of healthy donors as well as in blood serum of patients with chronic gastritis and with stomach cancer. Concentration of fucose was increased in blood serum under conditions of the tumor generalization. At the same time, content of fucosylated albumin was elevated within early steps of stomach cancer, while the content of fucosylated globulins was decreased. Estimation of albumin-bound fucose might be used in diagnosis of stomach cancer.

[The degree of modification of serum albumin as a toxicological test]. / Stepen' modifikatsii syvorotochnogo al'bumina kak toksikologicheskii test.

A procedure is developed, involving electrophoresis and TCA-ethanol treatment of electrophoregramms, which enabled to estimate quantitatively the modified derivatives of albumin just in blood serum without the protein isolation. The method is based on ability of native albumin to maintain its solubility after TCA-ethanol treatment. At the same time, modified albumin with conformational alterations was fixed on a carrier and might be estimated using colorimetry or densitometry. The procedure developed might be used in chemical industry for evaluation of toxic effects of some substances.

[Properties of human serum albumin in ischemic heart disease]. / Svoistva al'bumina syvorotki krovi cheloveka pri ishemicheskoi bolezni serdtsa.

Conformational changes in blood serum albumin under heart ischemia are found from the dispersion parameters of optical rotation and circular dichroism. It is also found that patients with myocardium infarction have a considerable amount of carbohydrate components in the modified albumin form.

[Transient form of serum albumin in gynecologic cancer]. / Tranzitornaia forma al'bumina krovi pri onkoginekologicheskikh zabolevaniiakh.

The frequency of diagnostic errors in examination of 3827 patients with gynecological cancer diseases accounted for 21.6 up to 35%. The conformation of serum albumin in these patients was studied by means of different biochemical assays. The determination of the amount of the transitory form of albumin by reprecipitation with trichloroacetic acid appeared the most valuable for practical uses. Structural injuries to albumin depended on the localization, pattern and stage of the disease, and features of tumor metastatic spreading. The amount of the transitory form in patients with benign tumors and tumor-like processes in the ovaries (4.5-23.5%), hydatidiform mole (25%), uterine myoma (2-12.6%) rose insignificantly (5 +/- 2% in control) and increased in patients with initial stages of malignant tumors of the ovaries and uterus (28.9-43.7%). In uterine cervix carcinoma and uterine body sarcoma (stage II and higher stages) as well as in ovarian carcinoma, stages III and IV, its amount reached 57-100%.