ABSTRACT
INTRODUCTION: Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma that most commonly affects men above the age of 60 years. The disease is called MCL because the tumor cells originate from the mantle zone of the lymph node. The most commonly affected sites are the lymph nodes, bone marrow, gastrointestinal tract, Waldeyer's ring and rarely the skin, breast and central nervous system. Only 22 cases with skin manifestation of MCL have been reported so far. CASE: We report the case of a 73-year-old woman who was diagnosed with MCL and underwent treatment, but later relapsed and presented with an ulcerated mass over her right foot. She underwent 6 cycles of chemotherapy with bendamustine plus rituximab and responded with resolution of the foot lesion. DISCUSSION AND CONCLUSIONS: MCL is an aggressive lymphoma with a median overall survival of 3-5 years for advanced disease, while early-stage disease has a better prognosis. It rarely involves the skin. Since cutaneous lesions can be the first manifestation of MCL, awareness of this less common presentation is crucial to establish an early diagnosis and pursue treatment as early as possible, as it significantly impacts the survival rate.
Subject(s)
Foot Ulcer/diagnosis , Lymphoma, Mantle-Cell/diagnosis , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Bone Marrow/pathology , Diagnosis, Differential , Female , Foot Ulcer/drug therapy , Humans , Immunophenotyping , Lymphoma, Mantle-Cell/drug therapy , Positron Emission Tomography Computed Tomography , Positron-Emission Tomography , Treatment OutcomeABSTRACT
We report a case of an orbital hemangiopericytoma (HPC) in a female infant diagnosed at 7 weeks of age. Cytogenetic analysis of the tumor revealed trisomy 15. To the authors' knowledge, this is only the second reported case of this chromosomal aberration being associated with HPC, both cases occurring in infants.
Subject(s)
Chromosomes, Human, Pair 15/genetics , Hemangiopericytoma/genetics , Orbital Neoplasms/genetics , Trisomy/genetics , Female , Gestational Age , Hemangiopericytoma/pathology , Hemangiopericytoma/surgery , Humans , Infant , Magnetic Resonance Imaging , Ophthalmologic Surgical Procedures , Orbital Neoplasms/pathology , Orbital Neoplasms/surgery , Tomography, X-Ray ComputedABSTRACT
Giant cell tumor of bone is a benign, locally aggressive neoplasm that is composed of sheets of neoplastic mononuclear cells interspersed amongst non-neoplastic, uniformly distributed, osteoclast-like giant cells. They represent approximately 4-5% of primary bone tumors. Rarely, bone tumors have been noted to produce human chorionic gonadotropin, a finding most often reported in osteosarcoma. We present the case of a young woman who presented with a low-level human chorionic gonadotropin level which, after resection of her recurrent giant cell tumor of bone with secondary aneurysmal bone cyst-like change, became undetectable in her blood. Furthermore, cells within the aneurysmal bone cyst component were immunohistochemically positive for ß-human chorionic gonadotropin. This is the first report of such a finding in the literature.
Subject(s)
Bone Cysts, Aneurysmal/blood , Bone Cysts, Aneurysmal/diagnosis , Chorionic Gonadotropin, beta Subunit, Human/blood , Femoral Neoplasms/blood , Femoral Neoplasms/diagnosis , Giant Cell Tumor of Bone/blood , Giant Cell Tumor of Bone/diagnosis , Adolescent , Biomarkers, Tumor/blood , Bone Cysts, Aneurysmal/etiology , Diagnosis, Differential , Female , Femoral Neoplasms/complications , Giant Cell Tumor of Bone/complications , Humans , Tomography, X-Ray ComputedABSTRACT
OBJECTIVE: The study aimed to report the case of a patient with a polypoid vulvar lesion clinically thought to be an aggressive angiomyxoma. MATERIALS AND METHODS: On examination, a 4.0 × 2.0 × 1.5-cm polypoid lesion was seen on the right labium majus. RESULTS: Histopathological findings of the excised mass were consistent with pseudoangiomatous stromal hyperplasia of the vulva CONCLUSIONS: Pseudoangiomatous stromal hyperplasia is a lesion of breast tissue but can occur in anogenital mammary-like glands. It must be distinguished from low-grade angiosarcoma.
