Quantum-circuit black hole lasers.

A black hole laser in analogues of gravity amplifies Hawking radiation, which is unlikely to be measured in real black holes, and makes it observable. There have been proposals to realize such black hole lasers in various systems. However, no progress has been made in electric circuits for a long time, despite their many advantages such as high-precision electromagnetic wave detection. Here we propose a black hole laser in Josephson transmission lines incorporating metamaterial elements capable of producing Hawking-pair propagation modes and a Kerr nonlinearity due to the Josephson nonlinear inductance. A single dark soliton obeying the nonlinear Schrödinger equation produces a black hole-white hole horizon pair that acts as a laser cavity through a change in the refractive index due to the Kerr effect. We show that the resulting laser is a squeezed-state laser characterized by squeezing parameters. We also evaluate the degree of quantum correlation between Hawking and its partner radiations using entanglement entropy which does not require simultaneous measurements between them. As a result, the obtained entanglement entropy depending on the soliton velocity provides strong evidence that the resulting laser is derived from Hawking radiation with quantum correlation generated by pair production from the vacuum.

Floquet-engineered quantum walks.

The quantum walk is the quantum-mechanical analogue of the classical random walk, which offers an advanced tool for both simulating highly complex quantum systems and building quantum algorithms in a wide range of research areas. One prominent application is in computational models capable of performing any quantum computation, in which precisely controlled state transfer is required. It is, however, generally difficult to control the behavior of quantum walks due to stochastic processes. Here we unveil the walking mechanism based on its particle-wave duality and then present tailoring quantum walks using the walking mechanism (Floquet oscillations) under designed time-dependent coins, to manipulate the desired state on demand, as in universal quantum computation primitives. Our results open the path towards control of quantum walks.

[Successful long-term management of ovarian bleeding and menorrhagia with prothrombin complex concentrate in a patient with congenital factor X deficiency].

A female patient in her forties exhibited no evidence of abnormal bleeding at birth. At the age of 6 years, she experienced pain in bilateral thighs and knee joints without any occasion. Accordingly, the bleeding tendency was suspected, and the coagulation profile assessment revealed prolongation of the APTT (122 s). Further tests revealed a marked reduction in the factor X activity (FX:C) to 4.5%, and the patient was diagnosed with congenital factor X deficiency; at that time, the case was reported by Mori et al. (The Japanese Society of Hematology 43: 572-586, 1980). At the age of 19 years, she was transferred to our hospital, where both prolongation of the PT and APTT and reduction of FX:C to <1% were reconfirmed. During follow-up observation, the patient developed lower abdominal pain and severe anemia. Gynecological examination revealed ovarian bleeding with menorrhagia. Thus, she was prescribed low-dose pills for menorrhagia, which successfully arrested the progression of anemia for a long term. However, she underwent uterine myomectomy and developed anemia again because of menorrhagia. For controlling menorrhagia-caused severe anemia, we initiated the patient on FX replacement therapy with prothrombin complex concentrate, PPSB-HT "Nichiyaku," by self-infusion on day 1 of each monthly menstrual cycle. Since then, menorrhagia and severe anemia have remained under good control.

[Drug-induced immune hemolytic anemia caused by cefmetazole].

A 56-year-old female who was diagnosed with acute calculous cholecystitis received intravenous administration of cefmetazole (CMZ) from the day of admission; she underwent laparoscopic cholecystectomy on the 13th hospital day. She was referred to our department because of hematuria that persisted for 3 days and progressive anemia on the day after the surgery. Laboratory data showed the following results: hemoglobin (Hb) level, 6.8 g/dl; reticulocyte count, 3.4%; serum lactate dehydrogenase, 1,505 IU/l; serum creatinine, 1.1 mg/dl; and undetectable haptoglobin. The direct globulin test showed that the patient was positive for IgG. Thus, drug-induced immune hemolytic anemia (DIIHA) was considered. All drugs, including CMZ, were immediately discontinued, and steroid was administered. The signs of hemolysis began to subside 3 days after the initiation of steroid therapy, and the administration of steroid was discontinued on the 5th day of the treatment. The patient's Hb level gradually increased, and the direct globulin test showed that the patient was negative for IgG on the 21st day from the onset of hematuria. Antibodies against CMZ-coated red blood cells were observed in the serum preserved at the onset of hemolysis. DIIHA is a rare but life-threatening disease. Immediate discontinuation of any suspected drugs and the initiation of steroid therapy as necessary are important in cases wherein DIIHA is suspected.

An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform.

The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest for the height of acceleration peak. The peak time of acceleration, velocity, and ½ fibrin formation, and the width of acceleration and velocity were significantly long and the height of acceleration was significantly low in patients with hemophilia. The height of velocity was significantly low in patients with hemophilia with inhibitor. There were no significant differences in the APTT waveform between patients with hemophilia and patients with LA, but the peak of acceleration and ½ fibrin formation were significantly longer and the height of acceleration and velocity were significantly lower in patients with hemophilia with inhibitor than in the patients with LA. Wave changes in the APTT were observed in all 22 patients positive for LA, while a biphasic waveform was observed in patients with hemophilia with FVIII activity <10.0%. The APTT waveform is useful for the analysis of hemostatic abnormalities in patients with hemophilia.