ABSTRACT
Adult mice were given subcutaneous injections of purified penitrem A (10 mg/kg) dissolved in corn oil. The mycotoxin was prepared by ether extraction and absorption chromatography; identity was established by absorption and mass spectra. Tremors were sustained for 72 hr following a single dose; readministration every 3 days was used to provide continuous trembling for 18 days. No lesions specifically attributed to penitrem A could be detected by histological examination of brains even after 18 days of trembling. Pharmacological agents affecting central nervous system neurotransmitters had some capacity to modify the effects of penitrem A. The results of those studies were such that a definitive conclusion regarding mechanisms of action of the toxin could not be determined.
Subject(s)
Brain/pathology , Mycotoxins/toxicity , Tremor/physiopathology , Animals , Brain/drug effects , Male , Mice , Mice, Inbred ICR , Mycotoxins/isolation & purification , Time Factors , Tremor/chemically inducedABSTRACT
Electroencephalograms were recorded from 10 dogs before, immediately after, and every 10 minutes (for 60 minutes) after IV injection of 0.005 ml of a fentanyl citrate and droperidol combination/kg of body weight. Narcosis was adequate for recording. At 30 to 40 minutes after injection, tail wagging was the only adverse reaction (EEG artifact) observed. The only changes in EEG activity observed were a slight increase in amplitude of the dominant activity and an increase in spindle-like activity. Daily repetition for 5 days did not alter the EEG pattern or the behavior of the dogs.
Subject(s)
Brain/drug effects , Dogs/physiology , Droperidol/pharmacology , Electroencephalography/veterinary , Fentanyl/pharmacology , Immobilization , Animals , Brain/physiology , Droperidol/administration & dosage , Drug Combinations , Female , Fentanyl/administration & dosage , Injections, Intravenous/veterinary , MaleSubject(s)
Diabetes Mellitus/veterinary , Diabetic Neuropathies/veterinary , Dog Diseases/diagnosis , Animals , Biopsy/veterinary , Cystitis/complications , Cystitis/diagnosis , Cystitis/veterinary , Diabetes Complications , Diabetes Mellitus/diagnosis , Diabetic Neuropathies/complications , Diabetic Neuropathies/diagnosis , Dogs , Female , Humans , Muscles/pathology , Nerve Fibers/pathologyABSTRACT
Electroencephalograms of 20 dogs given succinylcholine and concurrent artificial respiration were recorded. The amplitudes of the fast activity of the electroencephalograms were approximately one-fifth that observed in awake dogs. In addition, the occurrence of slow waves (6 to 8 Hz) was more marked in those dogs treated with succinylcholine. Succinylcholine caused a low amplitude dominant activity with increased moderate amplitude low frequency waves.
