[The influence of mexidol on the liver functions, structure, and parameters of lipid peroxidation under long-term hypodynamia conditions].

It is established that rabbits kept under the conditions of 30-day hypodynamia with high-grade feeding exhibit disorders in both structure and functions of the liver, which are classified as nonalcoholic type fatness. Other disturbances are an increase in the activity of aspartate aminotransferase (AsAT) and alanine aminotransferase (AlAT) and a decrease in the total protein content predominantly at the expense of albumin. The development of a syndrome of mesenchymal inflammation is manifested by a relative growth of the alpha1, alpha2 and gamma-protein fractions. Pronounced violations of the lipid metabolism were manifested by a growth in the content of beta-lipoproteins, triglycerides, general cholesterol, and low-density lipoproteins and by a decrease in the level of high-density lipoproteins in the blood serum of animals. An increase in the content of malonic dialdehyde was accompanied by a drop in the activity of catalases in the blood serum and erythrocytes of rabbits. Investigation of the morphology of liver tissues showed evidence for small- and large-drop diffuse steatosis, which was most expressed in the central zones of lobes. Using of cytochrome C and mexidol, it is possible to reduce the expression of disorders to various degrees and, in some cases, to prevent the development of pathological changes.

[Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinate of the hepatotoxyc, caused at rats introduction tuberculostatics]. / Korrektsiia Meksidolom gepattoksichnosti, vyzyvaemoi u krys vvedeniem tuberkulostatikov.

Administration of toxic doses of means specific tuberculostatics chemotherapy to rats caused development of medicinal damages of liver, kidneys, and pancreas. Use of 2-ethyl-6-methyl-hydroxypyridine succinate (SEMOP) and S-adenosyl-L-methionine reduced manifestations of pathological effects of tuberculostatics an organism of laboratory animals. There was clear dose-dependence of SEMOP effects. The highest cytoprotective effect was observed at the SEMOP dose of 50 mg/kg. Antioxidant properties of SEMOP determined it membrane protective effects.

[Optimization of geriatric help for urban and rural residents of the Ulianovsk region]. / Optimizatsiia geriatricheskoi pomoshchi gorodskomu i sel'skomu naseleniiu Ul'ianovskoi oblasti.

The problem of ageing of the population presupposes the necessity of essential in medico-social services activity and the creations of some uniform coordinated help system for the slderly within the framwork of public health sevices anf social protection. On the basis of the carried out analysis of demographic, social, economic and medical parameters we have developed the plan of geriatric service in Ulyanovsk area. Ulyanovsk Regional Clinical Hospital of War Veterans took the leading part in this work. For the period of 1993-1997 there have been created three regional geriatric centres with branches of day-time departments for 75 places each as structural division of Ukyanovsk regional clinic hospital. In 1999 on the basis of local hospitals in rural areas we opened two interdistrict geriatric centres for 50 and 40 places as divisions of URCHWV. In their structure there are round-the-clock and day-time places, rooms of nurse care, rooms and services for rendering medical, pyschological and social rehabilitation. One-place cost in 2001 has made 210 roubles, that is 1.5-2 times lower, than in city hospitals. As a result of the carried out treatment 88.3% of patients left the hospital with improvement, 9.6% of them--without changes and 1.7%--with deterioration. This form of specialized medical geriatric help to the person living in the countryside, which includes stationary help, stationary-substituted technologies, rooms of a nurse care, social and labour rehabilitation, proves its solvency and expediency in medical and pharma-economic aspects and may be recommended to introduction in practical public health services.

[Efficacy of galstena in liver damage induced by antitubercular agents]. / Effektivnost' galsteny pri povrezhdenii pecheni protivotuberkuleznymi sredstvami.

It is established that galstena possesses hepatoprotector activity and is capable of reducing pathological changes in animals treated with toxic doses of antituberculous drugs. Galstena prevents from the development of cytolysis, as evidence by inhibition of the activity of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. The anti cholestatic effect of galstena is confirmed by suppression of the growth in the levels of total bilirubin, alkaline phosphatase, and gamma-glutarate transpeptidase. Galstena was also found to possess antiinflammatory properties. Moreover, a growth in the activity of glutathione-dependent reductase (related to inhibited growth of the iron level in the blood serum) is evidence of the antioxidant activity. In addition, galstena prevents from an increase in the content of creatinine and urea, which is evidenced of decreasing endogenous intoxication.

[Use of the plant hepatoprotector Galstena tuberculostatics-induced hepatic lesions: experimental and clinical study]. / Ispol'zovanie gepatoprotektora rastitel'nogo proiskhozhdeniia galsteny pri porazheniiakh pecheni tuberkulostatikami (éksperimental'no-klinicheskoe issledovanie).

The efficiency of the use of the natural drug Galstena (Richard Bittner GmbH) was experimentally and clinically studied on a model of damage induced by toxic doses of tuberculostatics (rifampicin, isoniazid, pyrazinamide) in laboratory rats and in patients with different forms of pulmonary tuberculosis and with hepatitis caused by specific antituberculous drug therapy, who were treated at the Clinic of Phthiziology. Galstena was found to have marked hepatoprotective properties and to be able to prevent renal and pancreatic disorders. The drug also showed an antioxidative activity. The use of Galstena in patients with pulmonary tuberculosis substantially reduced the magnitude of clinical and laboratory signs of drug-induced hepatic damage.

[Hepatoprotective effect of plant preparations]. / Gepatoprotektornoe deistvie preparatov rastitel'nogo proiskhozhdeniia.

The hepatoprotector activity of original compositions of plant origin, containing beet and carrot juices, decoction of dog rose fruits, and extracts of corn silk, peppermint leaves, and common horsetail herbs was studied on an acute hepatitis model induced by tetrachloromethane. An analysis of the data on the hepatocyte cytolysis, cholestasis, lipid peroxidation, and antioxidant system of blood serum showed that the preparations possess membranoprotector and antioxidant properties. This was manifested by a decrease in the activity of alanine aminotransferase and in the levels of total bilirubin and the final (malonaldehyde) and intermediate (diene conjugates) lipid peroxidation products, and by the absence of decline in the level of endogenous alpha-tocopherol and in the activity of glutathione-dependent enzymes.

[Effect of mexidol on the homeostasis and lipid peroxidation in paracetamol poisoning]. / Vliianie meksidola na sostoianie gomeostaza i perekisnoe okislenie lipidov pri intoksikatsii paratsetamolom.

It is established that mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) influences the state of homeostasis in guinea pigs intoxicated with paracetamol. Paracetamol administered in toxic doses disturbs the functions of liver and kidneys, violates the lipid, carbohydrate, and mineral metabolism, activates the lipid peroxidation (LPO) process, and decreases the level of antioxidant protection. Treatment of the test animals with mexidol (25 mg/kg) decreases the cytolysis of hepatocytes, the development of cholestasis, the degree of hepatocellular insufficiency, the growth of endogenous intoxication, the drop of calcium content, the growth of iron content in the blood serum, and the content of final LPO products. The mexidol treatment activated the enzymatic chain of the antioxidant system.

[Effect of plant preparations on lipid peroxidation parameters in acute toxic hepatitis]. / Vliianie sredstv rastitel'nogo proiskhozhdeniia na pokazateli perekisnogo okisleniia lipidov pri ostrom toksicheskom gepatite.

The influence of the original vegetable complexes (which include: juices of beet-rout and carrot, decoction of degrose berries, extracts of corn silk, leaves of peppermint and some other components) on the indicators of the cytolysis, lipid peroxidation and antioxidant system of serum of the laboratory rats with acute toxic hepatitis, was investigated. The vegetable complexes exhibited antioxidant effects which were proved by the reduction of the final and intermediate products of lipoperoxidization, the absence of decline of the level of endogenous alpha-tocopherol content and glutathione dependent enzymes.