ABSTRACT
In acute experiments on anesthetized dogs dopamine (10 micrograms/kg and 10 micrograms/kg/min) was shown to increase significantly the blood supply to ischemic regions and the minute heart volume at the background of insignificant systemic hypotension and tachycardia. When administered in a dose of 10 micrograms/kg/min dopamine increased the magnitude of the ratio of glycogen-phosphorylase b activity to total glycogen-phosphorylase activity in the blood plasma. Administration of 20 micrograms/kg of the drug did not produce a significant increase of the blood supply to ischemic regions and the minute heart volume in the presence of the tendency toward systemic hypotension and bradycardia.
Subject(s)
Coronary Disease/drug therapy , Dopamine/pharmacology , Hemodynamics/drug effects , Acute Disease , Animals , Collateral Circulation/drug effects , Collateral Circulation/physiology , Coronary Disease/enzymology , Coronary Disease/physiopathology , Dogs , Dopamine/therapeutic use , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Hemodynamics/physiology , Male , Time FactorsABSTRACT
In acute experiments on anesthetized cats the effect of dopamine administered in doses of 1, 5, 10 and 20 g/kg intravenously and 10 g/kg/min by intravenous drip was studied. The drug (10 g/kg and 10 g/kg/min) was found to cause a significant and prolonged increase of total coronary blood flow, a growth of oxygen consumption by the myocardium, a decrease of oxygen tension in the heart muscle against the background of poorly pronounced arterial hypertension during a simultaneous administration and tendency towards arterial hypotension. When administered in doses of 1 and 5 g/kg intravenously dopamine induced little positive shifts of the parameters under study, and in a dose of 20 g/kg intravenously decreased total coronary blood flow, oxygen consumption by the heart and increased oxygen tension in the myocardium against the background of moderate arterial hypertension.
