Subject(s)
Respiratory Distress Syndrome/etiology , Wounds and Injuries/complications , Acute Disease , Blood Platelets/physiology , Capillary Permeability , Humans , Leukocytes/physiology , Lung/physiopathology , Pneumonia/etiology , Pneumonia/physiopathology , Pulmonary Circulation , Respiration , Respiratory Distress Syndrome/physiopathology , Respiratory Distress Syndrome/therapy , Shock, Hemorrhagic/etiology , Shock, Hemorrhagic/physiopathology , Shock, Traumatic/complications , Wounds and Injuries/physiopathology , Wounds and Injuries/therapyABSTRACT
On the basis of experimental and clinical studies the authors recommend to use mebikar with promedol in complex with other drugs for the treatment of traumatic shock in the prehospital and hospital periods. It was found to substantially improve results of the antishock therapy.
Subject(s)
Aminopyrine/analogs & derivatives , Biureas/administration & dosage , Dipyrone/administration & dosage , Meperidine/analogs & derivatives , Promedol/administration & dosage , Shock, Traumatic/drug therapy , Acid-Base Equilibrium , Adolescent , Adult , Aged , Animals , Catecholamines/blood , Cholinesterases/blood , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Monoamine Oxidase/blood , Rats , Shock, Traumatic/bloodABSTRACT
The effect of mebikar upon the course of traumatic shock was studied on the basis of experimental investigations and clinical observations. The authors have found a positive effect of the drug on indices of acid-base state, histostructure and cellular composition of the liver whose disturbance has a great pathogenetic significance in shock. The application of mebikar considerably improved the results of treatment in clinic and reduced lethality in experiment. It was supposed that the positive effect of the drug was associated with prevention of the development of circulatory disorders and with the maintenance of oxidation-reduction process and the histostructure of tissues.
Subject(s)
Biureas/therapeutic use , Bridged Bicyclo Compounds/therapeutic use , Bridged-Ring Compounds/therapeutic use , Shock, Traumatic/drug therapy , Tranquilizing Agents/therapeutic use , Acid-Base Equilibrium/drug effects , Adult , Animals , Drug Evaluation , Drug Evaluation, Preclinical , Humans , Liver/drug effects , Male , RatsABSTRACT
When characterising the so called disputable and indisputable points in the traumatic shock problem, the authors acquaint the reader with phases of the development of shock and with its symptoms, which facilitates significantly diagnostic possibilities and allows to follow the dynamics of the disease. The physicians will benefit from the scheme of antishock therapy suggested by the authors.