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1.
Chem Commun (Camb) ; 59(98): 14587-14590, 2023 Dec 07.
Article in English | MEDLINE | ID: mdl-37991259

ABSTRACT

We report an elastic crystal of a copper(II) porphyrinato complex that exhibits slow magnetic relaxations and is a promising candidate for an external-force-responsive spin qubit.

2.
Sci Rep ; 13(1): 2233, 2023 02 14.
Article in English | MEDLINE | ID: mdl-36788295

ABSTRACT

Neural regeneration is extremely difficult to achieve. In traumatic brain injuries, the loss of brain parenchyma volume hinders neural regeneration. In this study, neuronal tissue engineering was performed by using electrically charged hydrogels composed of cationic and anionic monomers in a 1:1 ratio (C1A1 hydrogel), which served as an effective scaffold for the attachment of neural stem cells (NSCs). In the 3D environment of porous C1A1 hydrogels engineered by the cryogelation technique, NSCs differentiated into neuroglial cells. The C1A1 porous hydrogel was implanted into brain defects in a mouse traumatic damage model. The VEGF-immersed C1A1 porous hydrogel promoted host-derived vascular network formation together with the infiltration of macrophages/microglia and astrocytes into the gel. Furthermore, the stepwise transplantation of GFP-labeled NSCs supported differentiation towards glial and neuronal cells. Therefore, this two-step method for neural regeneration may become a new approach for therapeutic brain tissue reconstruction after brain damage in the future.


Subject(s)
Brain Injuries, Traumatic , Neural Stem Cells , Mice , Animals , Hydrogels , Neurons , Brain Injuries, Traumatic/therapy , Tissue Engineering/methods , Tissue Scaffolds , Biocompatible Materials , Cell Differentiation
3.
Nat Commun ; 13(1): 6213, 2022 10 20.
Article in English | MEDLINE | ID: mdl-36266283

ABSTRACT

Living organisms share the ability to grow various microstructures on their surface to achieve functions. Here we present a force stamp method to grow microstructures on the surface of hydrogels based on a force-triggered polymerisation mechanism of double-network hydrogels. This method allows fast spatial modulation of the morphology and chemistry of the hydrogel surface within seconds for on-demand functions. We demonstrate the oriented growth of cells and directional transportation of water droplets on the engineered hydrogel surfaces. This force-triggered method to chemically engineer the hydrogel surfaces provides a new tool in addition to the conventional methods using light or heat, and will promote the wide application of hydrogels in various fields.


Subject(s)
Hydrogels , Water , Hydrogels/chemistry , Water/chemistry
4.
Gan To Kagaku Ryoho ; 47(10): 1497-1500, 2020 Oct.
Article in Japanese | MEDLINE | ID: mdl-33130749

ABSTRACT

A 22-year-old male was diagnosed with a metastatic nonseminomatous germ cell tumor in the mediastinum with an elevated serum alpha-fetoprotein(AFP)concentration. Histopathological findings following percutaneous biopsy revealed the presence of a mature teratoma. Bleomycin, etoposide, and cisplatin(BEP)chemotherapy resulted decreased his serum AFP. However, the tumor became enlarged and was deemed inoperable due to size. Radiographic examination indicated diffuse calcification of the tumor mass. Growing teratoma syndrome in a patient with a primary mediastinal nonseminomatous germ cell tumor is extremely rare.


Subject(s)
Mediastinal Neoplasms , Neoplasms, Germ Cell and Embryonal , Teratoma , Testicular Neoplasms , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Bleomycin/adverse effects , Cisplatin/adverse effects , Etoposide , Humans , Male , Mediastinal Neoplasms/drug therapy , Mediastinum , Neoplasms, Germ Cell and Embryonal/drug therapy , Teratoma/drug therapy , Testicular Neoplasms/drug therapy , Young Adult
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