ABSTRACT
The detectability of delta-infection among patients with HB virus infections and their effects on the course of hepatitis B are discussed. Anti-delta were detected in 25.2% of 111 patients with HB virus infections. The course of the disease was more severe in cases of combined infection, and delta-superinfection was associated with the clinical picture of CAH, suggesting that combined B + delta infection may be producing a profound liver damage.
Subject(s)
Hepatitis B/complications , Hepatitis D/complications , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Hepatitis Antibodies/analysis , Hepatitis D/diagnosis , Hepatitis D/immunology , Hepatitis Delta Virus/immunology , Humans , Infant , Male , Middle AgedABSTRACT
The therapeutic efficacy of human leucocytic alpha-interferon and combiferon produced in the N.F. Gamaleya Institute of Epidemiology and Microbiology, was assessed in 27 patients with different types of hepatitis B and in 30 controls. A marked clinical effect was noted in therapy of acute types of hepatitis B: the improvement of clinical and immunological indices, the reduction of the duration of HBs-antigenemia. The treatment of chronic types was effective in 5 out of 8 patients. A therapeutic scheme for acute and chronic types of hepatitis B was given.
Subject(s)
Hepatitis B/drug therapy , Interferon Type I/therapeutic use , Acute Disease , Adult , Child, Preschool , Chronic Disease , Clinical Trials as Topic , Drug Combinations/therapeutic use , Female , Hepatitis B/immunology , Humans , Immunity, Cellular/drug effects , Interferon Type I/administration & dosage , Interferon alpha-2 , Interferon-alpha , Male , Middle Aged , Recombinant ProteinsABSTRACT
Patients of different age, among them 103 with viral hepatitis B and 120 with viral hepatitis A, were examined for immunoregulatory subpopulations of T lymphocytes and for the effects of HBsAg preparations and human liver-specific lipoprotein (LSL) on the blood E-RFC content. The patients of both mature and elderly age with viral hepatis A demonstrated insignificant, readily reversible alterations in cellular immunity. The patients with viral hepatitis B, particularly elderly ones, showed an evident tendency toward the predominance of the suppressor effects, which correlated with the disease gravity. During incubation of lymphocytes with HBsAg, the stimulating effect was mostly revealed. However, in elderly patients experiencing the stage of late convalescence, there was an increase in HBsAg-specific suppression depending on the disease gravity. The suppressive action of LSL was only recorded in single cases.
