ABSTRACT
In 77 patients with postinfarction cardiosclerosis the blood serum immunoglobulin level was studied along with some indices of the lipid and protein metabolism. An increased blood level of immunoglobulins A, M and G was observed in postinfarction cardiosclerosis cases, those with hyper-beta-lipoproteinemia, hypercholesterolemia and C-reactive protein having a significantly higher level of immunoglobulin G and than the rest of the patients. In those having an increased content of immunoglobulin G in the blood serum hypo-beta-globulinemia was observed, as well as a considerable increase of the gamma-globulin fraction as compared to those having a normal or decreased level of immunoglobulin G. Proceeding from these data the authors suggest the presence of autoimmune shifts in the patients with postinfarction cardiosclerosis that are closely connected with lipid and protein metabolism disorders.
Subject(s)
Antigen-Antibody Reactions , Coronary Disease/immunology , Myocardial Infarction/immunology , Adult , Aged , Autoantibodies/analysis , Blood Proteins/analysis , C-Reactive Protein/analysis , Cholesterol/blood , Female , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Middle Aged , Serum Albumin/analysis , Serum Globulins/analysisABSTRACT
The blood levels of catecholamines, serotonin, histamine and acetylcholine were studied in 17 patients with severe and moderate coronary shock. The blood level of the above vasoactive substances varied widely, and no clear regularity was noted in the changes of the content of the catecholamines, histamine, serotonin and acetylcholine. A relatively higher (on the average) level of noradrenaline was noted in severe shock, in contrast to the moderate cases, as well as a relatively low level of noradrenaline and acetylcholine in the blood of patients with a full atrioventricular block and bradycardia. In studying the vasoactive substances dynamically similar, phase-like fluctuations of the blood level of histamine and serotonin were noted in some patients. In a few cases similar, often phase-like, changes were also noted in the blood content of noradrenaline and acetylcholine
