ABSTRACT
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573. This strain was identified as Coleophoma empetri No. 14573 from morphological and physiological characteristics. FR220897 and FR220899 showed antifungal activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis. Furthermore, FR220897 was effective in a murine model of systemic candidiasis.
Subject(s)
Antifungal Agents/isolation & purification , Fungi/classification , Lipoproteins/isolation & purification , Peptides, Cyclic/isolation & purification , Animals , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Candida albicans/drug effects , Candidiasis/drug therapy , Fermentation , Fungi/metabolism , Lipoproteins/chemistry , Lipoproteins/pharmacology , Mice , Peptides, Cyclic/chemistry , Peptides, Cyclic/pharmacologyABSTRACT
FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.
