ABSTRACT
A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was removed and histologically was found to be a neurinoma originating from the right ninth intercostal nerve radicle. Soon after the operation, galactorrhoea, amenorrhoea and neurological symptoms disappeared. Prolactin levels normalized at 346 mU/l. These findings indicate that hyperprolactinaemia occurred as a result of the stimulation of afferent fibres from an intercostal nerve in a patient with intradural neurinoma of the intercostal nerve radicle.
Subject(s)
Amenorrhea/etiology , Galactorrhea/etiology , Intercostal Nerves , Neurilemmoma/complications , Peripheral Nervous System Neoplasms/complications , Spinal Cord Neoplasms/complications , Adult , Female , Humans , Magnetic Resonance ImagingABSTRACT
To elucidate the associations of the HLA class II alleles with Graves' disease (GD), we examined DRB1, DQA1, DQB1 alleles in 62 Japanese GD patients and 142 control subjects by the PCR-SSOP (polymerase chain reaction-sequence specific oligonucleotide probes) method. We found that DRB1*0803 (P < 0.02), DRB1*1403 (P < 0.03), DQA1*0103 (P < 0.02) alleles and DRB1*0803-DQA1*0103-DQB1*0601 (P < 0.01), DRB1*1403-DQA1*0501-DQB1*0301 (P < 0.02) haplotypes were significantly increased in GD patients. No DQB1 allele revealed a significant association with GD in Japanese. These weak associations may reflect either the heterogeneity of GD in Japanese or the importance of non-HLA factors in the development of the disease.
