1.
Bioorg Med Chem Lett
; 16(12): 3197-200, 2006 Jun 15.
Article
in English
| MEDLINE
| ID: mdl-16621549
ABSTRACT
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
Subject(s)
Aza Compounds/chemical synthesis , Aza Compounds/pharmacology , Factor VIIa/antagonists & inhibitors , Indoles/chemical synthesis , Indoles/pharmacology , Aza Compounds/chemistry , Crystallography, X-Ray , Factor VIIa/chemistry , Factor VIIa/metabolism , Indoles/chemistry , Models, Molecular , Molecular Structure , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 16(10): 2796-9, 2006 May 15.
Article
in English
| MEDLINE
| ID: mdl-16487703
ABSTRACT
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
