Therapeutic Management with Repurposing Approaches: A Mystery During COVID-19 Outbreak.

The ubiquitous pandemic that emerged due to COVID-19 affected the whole planet. People all over the globe became vulnerable to the unpredictable emergence of coronavirus. The sudden emergence of respiratory disease in coronavirus infected several patients. This affected human life drastically, from mild symptoms to severe illness, leading to mortality. COVID-19 is an exceptionally communicable disease caused by SARS-CoV-2. According to a genomic study, the viral spike RBD interactions with the host ACE2 protein from several coronavirus strains and the interaction between RBD and ACE2 highlighted the potential change in affinity from the virus causing the COVID-19 outbreak to a progenitor type of SARS-CoV-2. SARS-CoV-2, which could be the principal reservoir, is phylogenetically related to the SARS-like bat virus. Other research works reported that intermediary hosts for the transmission of viruses to humans could include cats, bats, snakes, pigs, ferrets, orangutans, and monkeys. Even with the arrival of vaccines and individuals getting vaccinated and treated with FDA-approved repurposed drugs like Remdesivir, the first and foremost steps aimed towards the possible control and minimization of community transmission of the virus include social distancing, self-realization, and self-health care. In this review paper, we discussed and summarized various approaches and methodologies adopted and proposed by researchers all over the globe to help with the management of this zoonotic outbreak by following repurposed approaches.

Highly fluorescent carbon dots derived from Mangifera indica leaves for selective detection of metal ions.

In this study, we report an inexpensive, green, and one-pot synthesis method for highly fluorescent carbon quantum dots (CQDs) using mango (Mangifera indica: M. indica) leaves to develop an efficient sensing platform for metal ions. The CQDs synthesized from M. indica leaves via pyrolysis treatment at 300 °C for 3 h were characterized by various spectroscopic and electron microscopy techniques for their structural, morphological, and optical properties. Accordingly, the synthesized CQDs showed an absorption peak at 213 nm to confirm the p-p* transition of the carbon core state, while the CQD particles were spherical with a size less than 10 nm. The prepared CQDs showed excellent fluorescent properties with blue emission spectra (around 525 nm) upon excitation at 435 nm. The synthesized CQDs had the prodigious sensing potential to detect Fe2+ ions in water with a limit of detection of 0.62 ppm. Additionally, their sensing capability was tested using a real sample (e.g., Livogen tablet). Moreover, the synthesized CQDs showed substantial stability over a long period (three months). Thus, this study provides an inexpensive and facile method for CQD-based sensing of Fe2+ ions with a photoluminescence quenching mechanism.