ABSTRACT
BACKGROUND: The interest in mass screening programs for the early detection of endometrial cancer (EC) has grown with the rising incidence of this disease. Preliminary programs directed at asymptomatic women with only one risk factor, i.e. age, have not been cost-effective. METHODS: In the current study, 597 asymptomatic women from 45-69 years of age with diabetes and/or hypertension were screened by Vabra (Berkeley Medevices Inc., Berkeley, CA) aspiration. RESULTS: Among the women with diabetes, 6.3% preinvasive lesions of the endometrium were found. This is significantly more than the rate among women with hypertension, which was 1.3% (P < 0.01). CONCLUSIONS: Regular mass screening programs for the early detection of EC should be directed at asymptomatic diabetic women 45 years of age or older. This study does not indicate that similar screenings would be effective for women with hypertension.
Subject(s)
Diabetes Mellitus/epidemiology , Endometrial Neoplasms/epidemiology , Hypertension/epidemiology , Mass Screening , Aged , Biopsy, Needle , Curettage , Endometrial Hyperplasia/epidemiology , Endometrial Hyperplasia/pathology , Endometrial Hyperplasia/prevention & control , Endometrial Neoplasms/pathology , Endometrial Neoplasms/prevention & control , Female , Finland/epidemiology , Humans , Incidence , Middle Aged , Neoplasms, Unknown Primary/epidemiology , Neoplasms, Unknown Primary/pathology , Neoplasms, Unknown Primary/prevention & control , Precancerous Conditions/epidemiology , Precancerous Conditions/pathology , Precancerous Conditions/prevention & control , Prevalence , Risk FactorsABSTRACT
PIP: The effects of different oral contraceptive combined preparations (Serial, Ovanon, Delpregnin, Lyndiol 2.5, Ovulen mite, Primovlar, Gentrol, and Anovlar) on vaginal cytology during different phases of the menstrual cycle were studied. The karyopyknotic index was determined by phase contrast in 1301 patients and in 2213 controls. The results revealed great differences in estrogen activity and individual modes of action of progestin based on the cyclical pattern. It was established that vaginal cytology is an applicable and convenient method of comparing biological and especially estrogenic activities of different OCs as well as the reciprocal effect of different progestational steroids, and it is recommended that this method should be used in testing new preparations.^ieng
