ABSTRACT
Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD). A statistical increase in LPx activity was obtained by SOD, MKH, DVPSe and DVPMKH. All chemotherapeutic agents reduced Px activity in a statistically significant manner. There was no statistical significance for the results regarding the effects of the administered substances on GSHPx activity. The results for DVP, SOD, MKH, DVPSOD, DVPSe and DVPMKH showed reduced XOD activity which was statistically significant, which was lowest in the case of MKH, while NAC and Se reduced the activity of this enzyme but statistically non significant. NAC, Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter.
Subject(s)
Anthracyclines/adverse effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Doxorubicin/adverse effects , Acetylcysteine/pharmacology , Analysis of Variance , Animals , Anthracyclines/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antioxidants/pharmacology , Catalase/drug effects , Cholic Acids/pharmacology , Doxorubicin/administration & dosage , Drug Interactions , Free Radical Scavengers/pharmacology , Glutathione Peroxidase/drug effects , Heart/drug effects , Lipid Peroxidation/drug effects , Liver/drug effects , Mice , Mice, Inbred BALB C , Peroxidase/drug effects , Prednisolone/administration & dosage , Prednisolone/adverse effects , Selenium/pharmacology , Superoxide Dismutase/pharmacology , Vincristine/administration & dosage , Vincristine/adverse effects , Xanthine Oxidase/drug effectsABSTRACT
Extracerebral hematomas, mostly caused by trauma, can be epidural or subdural according to their localization. According to their clinical picture they can be acute, subacute or chronic. Chronic epidural hematomas are extremely rare cases. Extracerebral hematomas are hemolyzed with time and fibrosis happens around them and, if not operated, they may appear finally as dural scars. Diagnostic and evolution of these hematomas can be presented by CT of the brain. They can be differential diagnostic problem in diagnosis of tumor of cranial bone, dura mater or brain. Definitive diagnosis is accomplished by pathoanatomic and pathohistologic examination. Treatment of these hematomas is mostly operative. This paper deals with a patient who suffered of completely organized dural scar that is very rare.
