ABSTRACT
This study investigated the combined influence of parental monitoring, community monitoring, and exposure to substance-using peers on early-onset alcohol use in a sample of American Indian adolescents in three Pacific Northwest tribal communities. We used structural equation modeling, including tests of indirect effects, in the investigation of 281 American Indian youth between ages 8 and 16 years at the time of consent. The effects of parental monitoring and community monitoring, mediated by friends' substance use, were examined in terms of youth alcohol use outcomes. Parental monitoring practices and contagion in peer substance use were proximal predictors of early-onset alcohol use and the mediating effect of friends' substance use was not significant. Community monitoring accounted for unique variance in affiliation with substance-using friends.
Subject(s)
Alcohol Drinking , Indians, North American , Peer Group , Adolescent , Child , Female , Humans , Male , Northwestern United StatesABSTRACT
Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inherited metabolic disorder of ketone metabolism, characterized by ketoacidotic episodes and often permanent ketosis. To date there are ~20 disease-associated alleles on the OXCT1 gene that encodes the mitochondrial enzyme SCOT. SCOT catalyzes the first, rate-limiting step of ketone body utilization in peripheral tissues, by transferring a CoA moiety from succinyl-CoA to form acetoacetyl-CoA, for entry into the tricarboxylic acid cycle for energy production. We have determined the crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. An interactive version of this manuscript (which may contain additional mutations appended after acceptance of this manuscript) may be found on the web address: http://www.thesgc.org/jimd/SCOT .
Subject(s)
Acidosis/genetics , Coenzyme A-Transferases/deficiency , DNA Mutational Analysis/methods , Mutation, Missense , Protein Interaction Maps , Coenzyme A-Transferases/chemistry , Coenzyme A-Transferases/genetics , Crystallography, X-Ray , Humans , Models, Molecular , Protein Interaction Domains and Motifs/genetics , Protein Interaction Maps/genetics , Protein Multimerization/genetics , Protein Structure, Quaternary/genetics , Protein Structure, Secondary/genetics , Structure-Activity RelationshipABSTRACT
Mothers and fathers of 163 5-year-olds were observed interacting with their children in dyads on 2 separate occasions on a familiar and unfamiliar cognitive activity. Within- and between-family comparisons were conducted. Few differences in the instruction provided by mothers and fathers appeared, and those that did were on the unfamiliar task. On this task, instruction by mothers, within and across families, was more responsive to children's changing skill than was instruction by fathers. Directive and disapproving comments by parents were related to poorer posttest performance by the child. High level of instruction by both parents was related to better posttest performance than was low level of instruction by parents. Contributions of parents to their children's cognitive development are discussed.
