[Activation of tumor tissue glycolysis by inorganic phosphate at low pH values]. / Aktivatsiia glikoliza opukholevoi tkani neorganicheskim fosfatom pri nizkikh znacheniiakh pH.

It was shown that the activating effect of inorganic phosphorus on glucose utilization by the tumour tissue in vitro was retained at low pH of the incubation medium. The 0.15M Na2HPO4 in tris-buffer solutions infusion at the moment of cessation of the tumour selfacidity under glucose infusion led to further decrease of the tumour tissue pH. The tumour tissue pH values of about 4.5--4.6 were obtained. It is recommended to use the solutions with inorganic phosphorus for acidifying the tumour tissue in optimisation of the complex therapy schemes.

[Differentiation of a transformed culture of L cells]. / Differentsirovka kletok transformirovannoi kul'tury linii L.

The cells of line L originated from the connective and adipose tissue of mice C3H were cultivated in nutrient medium with a 60% bovine serum. Some cells differentiated into adipose cells with formation of structures similar to normal adipose tissue. The occurring differentiation was evaluated by the formation of characteristic signetring cells whose cytoplasm was filled with neutral fat with a positive reaction for lipids in staining with a mixture of sudan III and sudan IV. The conclusion was drawn that prolonged existence of cells outside the organism (in vitro cultivation) and intracellular changes (accompanying the transformation), including those of mutation character, did not deprive the cells of their ability to differentiate.

[Effect of the influenza virus and its structural components on the animal immunocompetence system]. / Vliianie virusa grippa i ego strukturnykh komponentov na immunokompetentnuiu sistemu zhivotnykh.

The authors studied the effect of the influenza virus A (PR8/34) and of its structural components on the immunological reactivity of mice. The enzyme of the external coat of the influenza virus--neuraminidase--possessed an immunodepressive action. Administration of neuraminidase led to the elimination of sialic acids from the surface of lymphocytes and to the reduction of their electrophoretic mobility. The mechanism of the immunodepressive action of neuraminidase is discussed.

[Effect of streptovaricin on the multiplication of L line cells]. / O vliianii streptovaritsima na razmnozhenie kletok linii L.

An inhibitor of the reverse trascriptase-streptovaricin in a dose of 4 mkg/ml would induce an increase of the DNA amount in L cell nuclei, while its dosage of 8 mkg/ml decrease the amount of DNA, resulting in the differentiation of some population cells. Streptovaricin inhibited the L cell multiplication, rendering no significant effect on that of normal fibroblasts of C3H mice culture.

[Tilorone, a synthetic immunostimulator possessing antitumor activity]. / Tiloron--sinteticheskii immunostimuliator, obladaiushchii protivoopukholevoi aktivnost'iu.

The authors report the results of studies on antitumor, immunostimulating and interieron-inducing properties of diethylamine fluorene derivative--tiloron, synthesized at Odessa laboratories of IGIC of the Ukrainian SSR Academy of Sciences by the originally elaborated method. It was found that tiloron does not suppress leucopoiesis, stimulates a number of protective reactions of the organism, including the factors of humoral and cell immunity, especially manifested under immunosuppression. Tiloron is shown to possess the definite antitumor activity being retained in peroral administration of the drug. Tiloron used together with cytostatic agents results in enhanced suppression of experimental tumors growth. Antitumor and immunostimulating action of tiloron on the experimental patterns under study is believed by the authors to be somewhat related with its interieron-inducing ability.