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1.
Pediatr Neurol ; 34(2): 143-5, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16458829

ABSTRACT

Although typical and limited Mongolian spots are benign skin markings at birth which fade and disappear as the child grows, extensive Mongolian spots deserve special attention as possible indications of associated inborn error of metabolism. A few cases of extensive Mongolian spots in association with inheritable storage diseases have been reported. Some hypotheses have been put forward, but further investigation is necessary to elucidate the causative factors. This report describes three infants with generalized Mongolian spots, two infants with GM1 gangliosidosis type 1, and one in association with Hurler syndrome. Findings of generalized Mongolian spots in newborns may lead to an early detection and early treatment before irreversible organ damage occurs.


Subject(s)
Gangliosidosis, GM1/complications , Mongolian Spot/etiology , Mucopolysaccharidosis I/complications , Skin Neoplasms/etiology , Humans , Infant , Male , Mongolian Spot/pathology , Skin Neoplasms/pathology
2.
Dermatol Online J ; 11(2): 13, 2005 Aug 01.
Article in English | MEDLINE | ID: mdl-16150221

ABSTRACT

Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts. Usually, they present as soft, flesh-colored to slightly yellow dermal papules on the lower eyelids of healthy individuals. We report an 18-year-old man with rare presentation of eruptive syringomas involving his trunk and extremities, with linear arrangement on the arms and forearms. A biopsy obtained from the lesions of the dorsum of the hands showed eccrine syringoma with a lymphocytic inflammatory infiltration around superficial blood vessels and eccrine ducts. We used the 585-nm and 595-nm pulsed dye laser for treatment of inflammatory lesions of forearm and trunk with no success.


Subject(s)
Sweat Gland Neoplasms/pathology , Syringoma/pathology , Adolescent , Humans , Male
3.
Int J Dermatol ; 42(1): 45-52, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12581144

ABSTRACT

BACKGROUND: The histologic diagnosis of early mycosis fungoides (MF) can be difficult to establish in many instances because the subtle changes observed in patches of MF are also present in many inflammatory dermatoses. METHODS: To assess the frequency and significance of many of these histologic parameters, we retrospectively reviewed 50 slides from patients with documented MF in patch, plaque, and tumor stages. The diagnosis of MF was unequivocally established either by the progression of patients to advanced stages of the disease or by indubitable histologic findings. In the second phase of the study, we compared the histologic parameters observed in 24 patch stage MF patients with those in 24 non-MF patients. The non-MF group were patients whose pathologic pattern was suspicious for MF, but who definitely did not have MF on clinical grounds. The two groups were matched by histologic pattern. Two different observers evaluated the slides and the intensities of 32 histologic parameters were graded on a four-point scale to minimize the subjective variability in the histologic reports. RESULTS: On univariate analysis, the following parameters achieved significance in distinguishing MF from non-MF: Pautrier's microabscesses, haloed lymphocytes, disproportionate epidermotropism, epidermal lymphocytes larger than dermal lymphocytes, hyperconvoluted lymphocytes in the epidermis and dermis, absence of dyskeratosis, and papillary dermal fibrosis. None of these features proved to have additional discriminating power on multivariate analysis. CONCLUSIONS: The efficacy of single histologic features in the diagnosis of early MF is generally poor and, to discriminate MF from its inflammatory simulators, a combination of cytologic and architectural features must be used.


Subject(s)
Mycosis Fungoides/pathology , Skin Neoplasms/pathology , Adolescent , Adult , Age Distribution , Aged , Analysis of Variance , Biopsy, Needle , Female , Humans , Immunohistochemistry , Incidence , Logistic Models , Male , Middle Aged , Multivariate Analysis , Mycosis Fungoides/diagnosis , Mycosis Fungoides/epidemiology , Neoplasm Staging , Retrospective Studies , Risk Assessment , Sensitivity and Specificity , Sex Distribution , Skin Neoplasms/diagnosis , Skin Neoplasms/epidemiology
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