ABSTRACT
Antimicrobial activity of imipenem was measured using 4725 strains isolated from patients with complicated urinary tract infections (CUTIs) between 1988 and 2000. Imipenem was inactive against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, Enterococcus faecium and some non-fermenting Gram-negative rods. Resistant strains (MIC>16 mg/l) were observed in Staphylococcus haemolyticus (22%), Enterococcus faecalis (4%), Enterococcus avium (8%), Serratia marcescens (5%) and Pseudomonas aeruginosa (7%). Although the prevalence of imipenem-resistant strains of S. aureus, S. epidermidis and P. aeruginosa was sporadically high in some years, no steady increase was seen over the period. Resistant strains were rare in other major uropathogenic species. These results suggest that imipenem is still one of the most reliable antimicrobial drugs.
Subject(s)
Anti-Bacterial Agents/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Imipenem/pharmacology , Urinary Tract Infections/microbiology , Anti-Bacterial Agents/therapeutic use , Drug Resistance, Microbial , Gram-Negative Bacteria/isolation & purification , Gram-Positive Bacteria/isolation & purification , Humans , Imipenem/therapeutic use , Microbial Sensitivity Tests , Urinary Tract Infections/drug therapyABSTRACT
A 28-year-old man visited our hospital complaining of the ulcerous lower extremity. An angiography showed the stenosis of the dorsal digital artery. The clinical diagnosis was Buerger's disease. The administration of prostaglandin I2 (PG I2) and antithrombotic drug were done. The ulcerous lower extremity improved. But a computerized tomographic scan of the abdomen showed the bilateral hydronephrosis incidentally. A retrograde pyelography (RP) revealed the bilateral ureteral strictures. We suspected the etiology was the retroperitoneal fibrosis associated with Buerger's disease.
Subject(s)
Hydronephrosis/etiology , Hydronephrosis/therapy , Stents , Thromboangiitis Obliterans/complications , Adult , Anti-Inflammatory Agents/administration & dosage , Humans , Male , Prednisolone/administration & dosage , Retroperitoneal Fibrosis/etiology , Thromboangiitis Obliterans/drug therapyABSTRACT
We compared a polymerase chain reaction (PCR)-based assay with primers specific for the 16S rRNA gene of Ureaplasma urealyticum with culture techniques for detecting U. urealyticum from urethral swab samples obtained from 256 asymptomatic men. Of 24 samples positive for U. urealyticum by culture, 23 samples were positive by the PCR-based assay, whereas 2 of 232 samples with a negative culture were positive by the PCR-based assay. The sensitivity and specificity for the PCR-based assay compared to culture were 95.8% and 99.1%, respectively. Our results confirmed the validity of the PCR-based assay for identifying this pathogen from urethral swab samples. In this study, we also examined urethral swab samples obtained from 195 men with urethritis for the detection of U. urealyticum by this assay. U. urealyticum was detected in 1 (3.4%) of 29 men with gonococcal urethritis and 23 (13.9%) of 166 men with nongonococcal urethritis. This assay may be a relevant tool to diagnose urethral Ureaplasma infections.
